Effects of 12-week combined exercise therapy on oxidative stress in female fibromyalgia patients

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dc.authorscopusid37077994100
dc.authorscopusid57191926529
dc.authorscopusid42661653300
dc.authorscopusid23968920100
dc.authorscopusid6508166517
dc.contributor.authorSarıfakıo?lu, Ayşe Banu
dc.contributor.authorYıldırım Güzelant, Aliye
dc.contributor.authorÇelik Güzel, Eda
dc.contributor.authorGüzel, Savaş
dc.contributor.authorKızıler, Ali Rıza
dc.date.accessioned2022-05-11T14:09:55Z
dc.date.available2022-05-11T14:09:55Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractThe aims of this study were to investigate the effect of exercise therapy on the oxidative stress in fibromyalgia patients and relationship between oxidative stress and fibromyalgia symptoms. Thirty women diagnosed with fibromyalgia according to the American College of Rheumatology preliminary criteria, and 23 healthy women whose age- and weight-matched women were enrolled the study. Pain intensity with visual analog scale (VAS), the number of tender points, the fibromyalgia impact questionnaire (FIQ), the Beck depression inventory (BDI) were evaluated. The oxidative stress parameters thiobarbituric acid reactive substances, protein carbonyls, and nitric oxide, and antioxidant parameters thiols and catalase were investigated in patients and control group. After, combined aerobic and strengthen exercise regimen was given to fibromyalgia group. Exercise therapy consisted of a warming period of 10 min, aerobic exercises period of 20 min, muscle strengthening exercises for 20 min, and 10 min cooling down period. Therapy was lasting 1 h three times per week over a 12-week period. All parameters were reevaluated after the treatment in the patient group. The oxidative stress parameters levels were significantly higher, and antioxidant parameters were significantly lower in patients with fibromyalgia than in the controls. VAS, FIQ, and BDI scores decreased significantly with exercise therapy. The exercise improved all parameters of oxidative stress and antioxidant parameters. Also, all clinical parameters were improved with exercise. We should focus on oxidative stress in the treatment for fibromyalgia with the main objective of reducing oxidative load.
dc.identifier.doi10.1007/s00296-014-2978-2
dc.identifier.endpage1367
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue10en_US
dc.identifier.pmid24610539
dc.identifier.scopus2-s2.0-84918813183
dc.identifier.scopusqualityQ2
dc.identifier.startpage1361
dc.identifier.urihttps://doi.org/10.1007/s00296-014-2978-2
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5200
dc.identifier.volume34
dc.identifier.wosWOS:000342455600003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSarıfakıo?lu, Ayşe Banu
dc.institutionauthorYıldırım Güzelant, Aliye
dc.institutionauthorÇelik Güzel, Eda
dc.institutionauthorGüzel, Savaş
dc.institutionauthorKızıler, Ali Rıza
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofRheumatology International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFibromyalgia
dc.subjectOxidative stress
dc.subjectAntioxidant status
dc.subjectExercise
dc.subjectNitric-Oxide
dc.subjectLipid-Peroxidation
dc.subjectAntioxidant Status
dc.subjectSkeletal-Muscle
dc.subjectProtein
dc.subjectSerum
dc.subjectPain
dc.subjectRecommendations
dc.subjectDamage
dc.subjectAcid
dc.titleEffects of 12-week combined exercise therapy on oxidative stress in female fibromyalgia patients
dc.typeArticle

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