Relationship between Lung Functions and Extent of Emphysema in Patients with Chronic Obstructive Pulmonary Disease

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dc.contributor.authorSarıaydın, Muzaffer
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorİnce, Özgür
dc.date.accessioned2022-05-11T14:39:47Z
dc.date.available2022-05-11T14:39:47Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: A study was undertaken to investigate whether the extent of emphysema, visually confirmed by high-resolution computed tomography (HRCT), in patients with COPD was associated with different indices of lung function and health-related life quality of patients with COPD. Methods: Eighty-two patients with COPD underwent HRCT scanning; visual assessment of HRCT scan was used in the calculation of the assessment of the severity and extent of emphysematous destruction. The patients were clinically stable at the time of the evaluation. For all subjects, a detailed interview of disease history and symptoms, health-related quality of life (HRQL) measurement, and pulmonary function tests were performed. Results: The mean visual emphysema score in all patients was 2.10 +/- 1.26. While the mean emphysema score in patients with COPD GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage 3 was 2.88 +/- 1.01, it was 1.54 +/- 1.13 in patients with COPD GOLD stage 2 (p<0.001). There was a significant correlation between the percentage of pulmonary emphysema and the numbers of pack-years smoked (r=0.58, p<0.001). The visual emphysema score was inversely correlated with FEV1 (r=-0.56, p<0.0001), FVC (r=-0.38, p<0.001), FEV1/FVC (r=-0.43, p<0.001), PEF (r=-0.44, p<0,001) and with carbon monoxide diffusion capacity (DLCO) (r=-0.50, p<0.001). There was no correlation between emphysema score and SGRQ. Conclusion: These data suggest that HRCT visual scores correlate with functional indices of airflow obstruction and impaired lung diffusing capacity in patients with stable chronic obstructive pulmonary disease of varying severity, and the presence of pulmonary emphysema is best represented by FEV1 and DLCO.
dc.identifier.doi10.5152/ejp.2014.98608
dc.identifier.endpage163
dc.identifier.issn2148-3620
dc.identifier.issn2148-5402
dc.identifier.issue3en_US
dc.identifier.startpage159
dc.identifier.urihttps://doi.org/10.5152/ejp.2014.98608
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8718
dc.identifier.volume16
dc.identifier.wosWOS:000421899100005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAltıntaş, Nejat
dc.language.isoen
dc.publisherAves
dc.relation.ispartofEurasian Journal of Pulmonology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic obstructive
dc.subjectcomputed tomography
dc.subjectemphysema
dc.subjectpulmonary disease
dc.titleRelationship between Lung Functions and Extent of Emphysema in Patients with Chronic Obstructive Pulmonary Disease
dc.typeArticle

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