Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal involvement: A Multicenter Observational Study

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dc.authoridKILINC, FADIME/0000-0001-9137-2675
dc.contributor.authorPolat, Asude Kara
dc.contributor.authorMulayim, Mehmet Kamil
dc.contributor.authorGur, Tugba Falay
dc.contributor.authorAcar, Ayda
dc.contributor.authorBozca, Burcin Cansu
dc.contributor.authorCeylan, Can
dc.contributor.authorKilinc, Fadime
dc.date.accessioned2024-10-29T17:59:51Z
dc.date.available2024-10-29T17:59:51Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesien_US
dc.description.abstractIntroduction: Pemphigus vulgaris (PV) is an autoimmune disease primarily affecting the oral mucosa. Objectives: This study aimed to determine the demographic, clinical and treatment characteristics of PV patients with oral mucosal involvement and to assess the impact on their quality of life. Methods: We conducted a prospective observational study among 106 patients diagnosed with PV and presenting oral mucosal involvement. Demographic data, clinical and treatment characteristics, and quality of life questionnaires were recorded. Results: The study included 106 patients, 55 (51.89%) were male and there was a predominance of the mucocutaneous subtype in 83 individuals (78.38%). Oral mucosa was the initial site of manifestation in 44 patients (41.51%). Bilateral buccal mucosa was the most frequently affected site. The predominant symptom reported was a burning sensation, noted in 91 patients (85.85%). Oral mucosal examination revealed erosions in 85.85% of the patients. Systemic steroids were the most commonly administered treatment, and rituximab was used in 18 patients (16.98%). A positive and significant correlation was found between pemphigus severity and Oral Health Impact Profile-14, Dermatology Life Quality Index and Dermatological Quality of Life Scale scores (P < 0.05). The presence of superficial ulcers, flaccid bullae, lesion diameter >= 1 cm, and >10 lesions were factors that markedly diminished quality of life. Complete response to treatment was noted in all patients administered rituximab. Conclusions: The most common area of involvement was bilateral buccal mucosa, and the severity of PV closely correlated with a decline in quality of life measures. These results highlight the need for careful clinical oversight of PV, taking into account its effects on patients quality of life.en_US
dc.identifier.doi10.5826/dpc.1402a99
dc.identifier.issn2160-9381
dc.identifier.issue2en_US
dc.identifier.pmid38810063en_US
dc.identifier.scopus2-s2.0-85191999986en_US
dc.identifier.urihttps://doi.org/10.5826/dpc.1402a99
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14855
dc.identifier.volume14en_US
dc.identifier.wosWOS:001228420100007en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofDermatology Practical & Conceptualen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectquality of lifeen_US
dc.subjectoral healthen_US
dc.subjectoral mucosaen_US
dc.subjectpemphigusen_US
dc.titleEvaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal involvement: A Multicenter Observational Studyen_US
dc.typeArticleen_US

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