The Effects of Ferulic Acid Against Oxidative Stress and Inflammation in Formaldehyde-Induced Hepatotoxicity

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dc.authorid0000-0002-1347-8498
dc.authorid0000-0002-0766-9159
dc.authorid0000-0002-2270-2965
dc.authorscopusid16042227300
dc.authorscopusid47561031200
dc.authorscopusid36023238400
dc.authorscopusid55515412500
dc.authorscopusid55858591400
dc.authorscopusid56040824100
dc.authorscopusid36866111300
dc.authorwosidUzun, Hafize/D-4811-2019
dc.authorwosidsener, umit/AAZ-7728-2020
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.contributor.authorGerin, Fethullah
dc.contributor.authorErman, Hayriye
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorŞener, Ümit
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorSeyhan, Hatice
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:10:11Z
dc.date.available2022-05-11T14:10:11Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractThis study was designed to elucidate the protective effects of ferulic acid (FA) on formaldehyde-induced hepatotoxicity by measuring some routine biochemical parameters, cytokine levels, and oxidative stress-related parameters in addition to YKL-40 in male Wistar albino rats. Tissue superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, and tissue malondialdehyde (MDA) levels were measured. Also, serum YKL-40, TNF-alpha, IL-6, IL-1 beta, IL-8, total protein, albumin, total bilirubin concentrations, and AST, ALT, ALP, and LDH activities were measured. Histological specimens were examined in light microscopy. Formaldehyde significantly increased tissue MDA, and serum cytokine levels and also decreased activities of antioxidant enzymes. FA treatment decreased MDA and cytokine levels and increased activities of antioxidant enzymes. FA also alleviated degeneration due to formaldehyde toxicity. We suggested that FA can be used as a promising hepatoprotective agent against formaldehyde toxicity because of the obvious beneficial effects on oxidative stress parameters.
dc.identifier.doi10.1007/s10753-016-0369-4
dc.identifier.endpage1386
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue4en_US
dc.identifier.pmid27235018
dc.identifier.scopus2-s2.0-84978946734
dc.identifier.scopusqualityQ2
dc.identifier.startpage1377
dc.identifier.urihttps://doi.org/10.1007/s10753-016-0369-4
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5319
dc.identifier.volume39
dc.identifier.wosWOS:000380232200011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGerin, Fethullah
dc.institutionauthorErman, Hayriye
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorŞener, Ümit
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorSeyhan, Hatice
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectferulic acid
dc.subjectformaldehyde
dc.subjectlipid peroxidation
dc.subjectantioxidants
dc.subjectYKL-40 protein
dc.subjectInduced Toxicity
dc.subjectSodium Ferulate
dc.subjectVitamin-E
dc.subjectYkl-40
dc.subjectLiver
dc.subjectExpression
dc.subjectChitinase
dc.subjectDamage
dc.subjectSerum
dc.subjectRats
dc.titleThe Effects of Ferulic Acid Against Oxidative Stress and Inflammation in Formaldehyde-Induced Hepatotoxicity
dc.typeArticle

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