Cardiovascular disease risk prediction in scleroderma

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dc.authoridÇELIKKOL, ALIYE/0000-0002-3799-4470
dc.authorwosidÇELIKKOL, ALIYE/ABE-2695-2020
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorMercan, Rıdvan
dc.contributor.authorGüzel, Savaş
dc.contributor.authorYılmaz, Ahsen
dc.date.accessioned2023-05-06T17:19:34Z
dc.date.available2023-05-06T17:19:34Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Cardiovascular disease risk prediction in scleroderma is important. In this study of scleroderma patients, the aim was to investigate the relationship between cardiac myosin-binding protein-C, sensitive troponin T, and trimethylamine N-oxide and cardiovascular disease risk with the Systematic COronary Risk Evaluation 2 model of the European Society of Cardiology.METHODS: Systematic COronary Risk Evaluation 2 risk groups of 38 healthy controls and 52 women with scleroderma were evaluated. Cardiac myosin-binding protein-C, sensitive troponin T, and trimethylamine N-oxide levels were analyzed with commercial ELISA kits.RESULTS: In scleroderma patients, cardiac myosin-binding protein-C and trimethylamine N-oxide levels were higher than healthy controls but sensitive troponin T was not (p<0.001, p<0.001, and p=0.274, respectively). Out of 52 patients, 36 (69.2%) were at low risk, and the other 16 (30.8%) patients were at high-moderate risk with the Systematic COronary Risk Evaluation 2 model. At the optimal cutoff values, trimethylamine N-oxide could discriminate high-moderate risk with sensitivity 76%, specificity 86% and cardiac myosin-binding protein-C with sensitivity 75%, specificity 83%. Patients with high trimethylamine N-oxide levels (>= 10.28 ng/mL) could predict high -moderate-Systematic COronary Risk Evaluation 2 risk 15 times higher than those with low trimethylamine N-oxide (<10.28 ng/mL) levels (odds ratio [OR]: 15.00, 95%CI 3.585-62.765, p<0.001). Similarly, high cardiac myosin-binding protein-C (>= 8.29 ng/mL) levels could predict significantly higher Systematic COronary Risk Evaluation 2 risk than low cardiac myosin-binding protein-C (<8.29 ng/mL) levels (OR: 11.00, 95%CI 2.786-43.430).CONCLUSION: Noninvasive cardiovascular disease risk prediction indicators in scleroderma, cardiac myosin-binding protein-C, and trimethylamine N-oxide could be recommended to distinguish between high-moderate risk and low risk with the Systematic COronary Risk Evaluation 2 model.
dc.identifier.doi10.1590/1806-9282.20220936
dc.identifier.endpage251
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue2en_US
dc.identifier.pmid36888764
dc.identifier.scopus2-s2.0-85149642577
dc.identifier.scopusqualityQ3
dc.identifier.startpage246
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20220936
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11858
dc.identifier.volume69
dc.identifier.wosWOS:000947881200011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelikkol, Aliye
dc.institutionauthorMercan, Rıdvan
dc.institutionauthorGüzel, Savaş
dc.institutionauthorYılmaz, Ahsen
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHeart disease risk factors
dc.subjectMyosin-binding protein C
dc.subjectScleroderma
dc.subjectsystemic
dc.subjectTroponin T
dc.subjectTrimethyloxamine
dc.subjectBinding Protein-C
dc.subjectSystemic-Sclerosis
dc.subjectClassification
dc.subjectBiomarkers
dc.subjectTroponin
dc.titleCardiovascular disease risk prediction in scleroderma
dc.typeArticle

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