The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazole on spatial learning and memory in rats

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dc.authorid0000-0001-7341-4907
dc.authorid0000-0002-1402-0163
dc.authorid0000-0001-5848-3680
dc.authorid0000-0002-8472-0261
dc.authorscopusid11440747800
dc.authorscopusid23991887300
dc.authorscopusid35386796500
dc.authorscopusid36739312100
dc.authorscopusid7003362092
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidTaşkın, Sabriye Karadenizli/F-6498-2018
dc.authorwosidYazır, YUSUFHAN/F-7289-2018
dc.authorwosidUtkan, Tijen/G-2398-2018
dc.authorwosidSahin, Deniz/AAT-3436-2021
dc.contributor.authorGöçmez, Semil Selcen
dc.contributor.authorYazir, Yusufhan
dc.contributor.authorŞahin, Deniz
dc.contributor.authorKaradenizli, Sabriye
dc.contributor.authorUtkan, Tijen
dc.date.accessioned2022-05-11T14:41:12Z
dc.date.available2022-05-11T14:41:12Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractSince the discovery of nitric oxide (NO) as a neuronal messenger, its way to modulate learning and memory functions is subject of intense research. NO is an intercellular messenger in the central nervous system and is formed on demand through the conversion of L-arginine to L-citrulline via the enzyme nitric oxide synthase (NOS). Neuronal form of nitric oxide synthase may play an important role in a wide range of physiological and pathological conditions. Therefore the aim of this study was to investigate the effects of chronic 3-bromo 7-nitroindazole (3-Br 7-NI), specific neuronal nitric oxide synthase (nNOS) inhibitor, administration on spatial learning and memory performance in rats using the Morris water maze (MWM) paradigm. Male rats received either 3-Br 7-NI (20 mg/kg/day) or saline via intraperitoneal injection for 5 days. Daily administration of the specific neuronal nitric oxide synthase (nNOS) inhibitor, 3-Br 7-NI impaired the acquisition of the MWM task. 3-Br 7-NI also impaired the probe trial. The MWM training was associated with a significant increase in the brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. BDNF mRNA expression in the hippocampus did not change after 3-Br 7-NI treatment. L-arginine significantly reversed behavioural parameters, and the effect of 3-Br 7-NI was found to be NO-dependent. There were no differences in locomotor activity and blood pressure in 3-Br 7-NI treated rats. Our results may suggest that nNOS plays a key role in spatial memory formation in rats. (C) 2015 Elsevier Inc All rights reserved.
dc.description.sponsorshipResearch Foundation of Kocaeli UniversityKocaeli University [200439]
dc.description.sponsorshipThe present study was supported by the Research Foundation (200439) of Kocaeli University.
dc.identifier.doi10.1016/j.pbb.2015.01.013
dc.identifier.endpage25
dc.identifier.issn0091-3057
dc.identifier.pmid25636602
dc.identifier.scopus2-s2.0-84964228138
dc.identifier.scopusqualityQ1
dc.identifier.startpage19
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2015.01.013
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9103
dc.identifier.volume131
dc.identifier.wosWOS:000352173200005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöçmez, Semil Selcen
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3-Br 7-NI
dc.subjectSpatial memory
dc.subjectNitric oxide
dc.subjectMorris water maze
dc.subjectLong-Term Potentiation
dc.subjectReceptor Antagonists
dc.subjectNeurotrophic Factor
dc.subjectTreated Rats
dc.subjectTask
dc.subjectInvolvement
dc.subjectPerformance
dc.subjectScopolamine
dc.subjectMolsidomine
dc.subjectDeficits
dc.titleThe effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazole on spatial learning and memory in rats
dc.typeArticle

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