Imiquimod 5% cream for isolated lichen planus of the lip

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dc.authorscopusid56074135100
dc.authorscopusid36728139600
dc.authorscopusid56223188000
dc.authorscopusid7005593922
dc.contributor.authorGencoglan, Gülsum
dc.contributor.authorİnanır, Isil
dc.contributor.authorŞahin, Onder
dc.contributor.authorGündüz, Kamer
dc.date.accessioned2022-05-11T14:36:54Z
dc.date.available2022-05-11T14:36:54Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractLichen planus (LP) of the lips is a rare condition that is generally associated with other parts of the oral mucosa. Lip localization has an increased risk, since external trauma, smoking and ultraviolet light trigger malignant transformation. Only a few cases of isolated LP of the lips have been reported up to now, but results of larger series on oral LP suggest that it might be underestimated. Treatment of oral LP is usually difficult and lesions are generally resistant or recur, so that novel therapy alternatives are necessary. Here we report four cases of isolated LP of the lip successfully treated with imiquimod 5% cream. It was applied twice daily, 5 days a week, for 2 weeks. Two weeks after therapy, complete clinical and histopathological resolution was observed. No recurrence was observed during the 5, 10 and 18 months' follow-up period in cases 4, 3 and 1, respectively. Clinical and histopathological cure was also observed in case 2, but the patient showed clinical activation after 6 months. We suggest that imiquimod 5% cream is a safe and effective therapeutic treatment for oral LP.
dc.identifier.doi10.3109/09546630903456367
dc.identifier.endpage59
dc.identifier.issn0954-6634
dc.identifier.issn1471-1753
dc.identifier.issue1en_US
dc.identifier.pmid20524879
dc.identifier.scopus2-s2.0-78650937550
dc.identifier.scopusqualityQ1
dc.identifier.startpage55
dc.identifier.urihttps://doi.org/10.3109/09546630903456367
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8466
dc.identifier.volume22
dc.identifier.wosWOS:000286812200011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Onder
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Dermatological Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMatrix Metalloproteinases
dc.titleImiquimod 5% cream for isolated lichen planus of the lip
dc.typeArticle

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