Evaluation of white matter integrity by diffusion tensor imaging in the deficiencies of vitamin B12 and folate in older patients

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dc.authoridKAYA, AHMET/0000-0002-8813-6513
dc.authoridToluk, Ozlem/0000-0001-6495-0839
dc.contributor.authorKaya, Ahmet
dc.contributor.authorAlkan, Alpay
dc.contributor.authorToluk, Ozlem
dc.contributor.authorIpar, Ozlem
dc.contributor.authorPolat, Yagmur Basak
dc.contributor.authorYabul, Fatma Celik
dc.contributor.authorBalsak, Serdar
dc.date.accessioned2024-10-29T17:58:50Z
dc.date.available2024-10-29T17:58:50Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjectives: The aim of this study is to investigate whether white matter (WM) integrity is impaired in vitamin B12 and folate deficiency with Diffusion Tensor Imaging (DTI) in older patients. Methods: All the patients aged & GE;65 years admitted to the geriatric clinic and performed DTI- MRI were included in the study. DTI parameters (fractional aniso-tropy, mean diffusivity, axial diffusivity, radial diffu-sivity) were calculated by ROI- based method in white matter tracts. Deficiency threshold for vitamin B12 were defined as <200 pg ml-1 and <400 pg ml-1 separately; and for folate as <3 ng ml-1 and <6 ng ml-1, separately.Results: DTI was performed to older patients having serum vitamin B12 level (n = 106, mean age = 80.7 & PLUSMN;7.7, 66% female) and folate level (n = 101, mean age = 80.7 & PLUSMN;7.5, 67.3% female). Significantly lower FA and higher MD and RD levels were observed in multiple WM areas including superior and middle cerebellar pedun-cles, cingulum and genu of corpus callosum in patients with vitamin B12 <400 pg ml-1 (p < 0.05). DTI indices also showed significant changes in the genu of corpus callosum, and right and left superior longitudinal fasciculus in patients with folate <6 ng ml-1(p < 0.05). Conclusions: Deficiencies of vitamin B12 and folate may be associated with impaired white matter integ-rity in elderly even at high laboratory levels, and DTI is a useful method to detect it. Advances in knowledge: Early detection of impaired WM integrity caused by micronutrient deficiencies poses a great significance in terms of prevention and intervention, and DTI is an effective non-invasive method to be used for this purpose.
dc.identifier.doi10.1259/bjr.20220415
dc.identifier.issn0007-1285
dc.identifier.issn1748-880X
dc.identifier.issue1148en_US
dc.identifier.pmid37335177
dc.identifier.scopus2-s2.0-85166001045
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1259/bjr.20220415
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14525
dc.identifier.volume96
dc.identifier.wosWOS:001046107100008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBritish Inst Radiology
dc.relation.ispartofBritish Journal of Radiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEvaluation of white matter integrity by diffusion tensor imaging in the deficiencies of vitamin B12 and folate in older patients
dc.typeArticle

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