Midkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients

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dc.authorid0000-0001-9238-3878
dc.authorscopusid23968920100
dc.authorscopusid56563019100
dc.authorscopusid42661653300
dc.authorscopusid55481926000
dc.authorscopusid6508166517
dc.authorscopusid34871426900
dc.authorscopusid6508253764
dc.authorwosidCinemre, Hakan/AAD-7506-2021
dc.authorwosidCavusoglu, Coskun/AAD-4119-2019
dc.contributor.authorGüzel, Savaş
dc.contributor.authorCinemre, Fatma Behice Serinkan
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorKüçükyalçın, Volkan
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorÇavuşoğlu, Coşkun
dc.contributor.authorAydemir, Birsen
dc.date.accessioned2022-05-11T14:12:34Z
dc.date.available2022-05-11T14:12:34Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.description.abstractBackground and Objectives: Hypertension (HT) is one of the risk factors associated with atherosclerosis. Midkine (MK) plays a role as a growth factor in various biologic and pathologic events. In some reports, MK expression has been shown to be linked with vascular smooth muscle proliferation and neo-angiogenesis in atherosclerotic vessels. The aim was to research relationship of MK serum levels with some atherosclerotic risk factors in hypertensive patients. Methodology: This study examined 60 patients with essential HT and 30 healthy controls. Serum biochemistry, including lipid profile, MK, Vitamin B 12, C-reactive protein, zinc and copper levels were obtained. Results: MK levels of the HT patients were significantly higher than the control group (24.8 +/- 6.8 ng/mL vs. 18.39 +/- 5.6 ng/mL, respectively, P < 0.01). Lipid profile parameters such as total cholesterol, triglyceride, low-density lipoprotein (LDL) were also significantly higher in HT patients (P < 0.021, P < 0.01, and P < 0.01, respectively). Zinc levels were 179.13 +/- 34.06 mu g/dL and 172.55 +/- 45.47 mu g/dL in the HT and control group, respectively. Serum MK levels were positively correlated with diastolic (r = 0.288, P < 0.05) and systolic blood pressures (r = 0.390, P < 0.002), and also with serum total cholesterol (r = 0.406, P < 0.002) and LDL cholesterol (r = 0.318, P < 0.015) levels. Furthermore MK was also negatively correlated with zinc and Vitamin B 12 levels (r = -0.298, P < 0.023, r = -0.334, P < 0.027, respectively). Conclusion: This study has demonstrated an important association between increased serum MK levels and risk factors of atherosclerosis such as HT, increased total and LDL cholesterol.
dc.identifier.doi10.4103/njcp.njcp_309_17
dc.identifier.endpage900
dc.identifier.issn1119-3077
dc.identifier.issue7en_US
dc.identifier.pmid29984722
dc.identifier.scopus2-s2.0-85050107987
dc.identifier.scopusqualityQ3
dc.identifier.startpage894
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_309_17
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5604
dc.identifier.volume21
dc.identifier.wosWOS:000439047000013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüzel, Savaş
dc.institutionauthorGüzel, Eda Çelik
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNigerian Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtherosclerosis
dc.subjectcholesterol
dc.subjecthypertension
dc.subjectmidkine
dc.subjectBinding Growth-Factor
dc.subjectExperimental Autoimmune Encephalomyelitis
dc.subjectZinc-Deficiency
dc.subjectBiological-Activities
dc.subjectDiabetic-Nephropathy
dc.subjectKidney-Diseases
dc.subjectInflammation
dc.subjectPleiotrophin
dc.subjectPathogenesis
dc.subjectAngiotensin
dc.titleMidkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients
dc.typeArticle

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