The role of serum Pro- and Anti-inflammatory cytokines as potential diagnostic markers for psoriasis

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dc.contributor.authorErdal, Berna
dc.contributor.authorAlbayrak, Hülya
dc.contributor.authorAydın Kurç, Mine
dc.contributor.authorVarol, Gamze
dc.contributor.authorYanık, Mehmet Emin
dc.contributor.authorErfan, Gamze
dc.contributor.authorGülen, Dumrul
dc.date.accessioned2022-05-11T14:10:03Z
dc.date.available2022-05-11T14:10:03Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Ana Bilim Dalı
dc.description.abstractAim: Cytokines secreted by T helper cell subgroups are considered to play chief roles in the complex pathobiology of psoriasis.Herein, we aimed to reveal the effects of anti- and pro-inflammatory cytokines on the pathobiology of psoriasis disease and thecorrelation of these cytokines with severity of psoriasis.Materials and Methods: Thirty-seven individuals diagnosed with psoriasis and 37 healthy control subjects were enrolled for thestudy. The levels of Tumor necrosis factor alpha (TNF?), Soluble CD40 ligand (sCD40L), Interferon gamma (IFN?) and Interleukin (IL)1?, IL4, IL6, IL10, IL17F, IL17A, IL21, IL22, IL23, IL25, IL31, IL33 were determined by the Luminex method.Results: The IL6, IFN?, TNF?, sCD40L, IL17F, IL17A, IL23, IL25, and IL31 levels were found to be markedly advanced in individualswith psoriasis in contrast to the control group (p=0.003, p=0.02, p<0.001, p=0.02, p=0.03, p=0.003, p=0.04, p=0.04, and p<0.001,respectively). No significant interrelation was found between the serum cytokine levels and severity of psoriasis (p>0.05).Conclusion: IFN?, IL6, TNF?, sCD40L, IL17F, IL17A, IL23, IL31, IL25 and inflammatory markers were markedly advanced in patients withpsoriasis, strongly supporting the notion that these cytokines are involved in the pathobiology of psoriasis disease. In conclusion,findings of the present study suggest that understanding of the functions of these cytokines in the complex pathogenesis of psoriasisdisease is of great interest for the future therapeutic intervention.
dc.identifier.doi10.5455/annalsmedres.2020.07.730
dc.identifier.endpage3111
dc.identifier.issn2636-7688
dc.identifier.issn2636-7688
dc.identifier.issue12en_US
dc.identifier.startpage3107
dc.identifier.trdizinidTkRJM09EZ3dNQT09
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2020.07.730
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRJM09EZ3dNQT09
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5268
dc.identifier.volume27
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorErdal, Berna
dc.institutionauthorAlbayrak, Hülya
dc.institutionauthorAydın Kurç, Mine
dc.institutionauthorVarol, Gamze
dc.institutionauthorGülen, Dumrul
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe role of serum Pro- and Anti-inflammatory cytokines as potential diagnostic markers for psoriasis
dc.typeArticle

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