Acromegaly is associated with a distinct oral and gut microbiota

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dc.authoridDemir, Ahmet Numan/0000-0002-9997-7051
dc.authoridDokmetas, Hatice Sebile/0000-0003-0300-4173
dc.authorscopusid57208882907
dc.authorscopusid57190258762
dc.authorscopusid56975479700
dc.authorscopusid6602975843
dc.authorscopusid23004514700
dc.authorscopusid57205466429
dc.authorscopusid57222493503
dc.authorwosidDemir, Ahmet Numan/AHD-5826-2022
dc.authorwosidDokmetas, Hatice Sebile/GSM-7199-2022
dc.authorwosidDURCAN, EMRE/AAB-9746-2020
dc.authorwosidDemir, Ahmet Numan/AEK-2338-2022
dc.contributor.authorŞahin, Serdar
dc.contributor.authorGündoğdu, Aycan
dc.contributor.authorNalbantoğlu, Ufuk
dc.contributor.authorKadıoğlu, Pınar
dc.contributor.authorKaraca, Züleyha
dc.contributor.authorHacıoğlu, Aysa
dc.contributor.authorKeleştimur, Fahrettin
dc.date.accessioned2023-04-20T08:01:16Z
dc.date.available2023-04-20T08:01:16Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose Our aim was to investigate the changes in the composition of oral and gut microbiota in patients with newly diagnosed acromegaly and their relationship with IGF-1 levels. Methods Oral and fecal samples were collected from patients with newly diagnosed acromegaly without comorbidities and from healthy controls. The composition of the microbiota was analyzed. The general characteristics, oral and stool samples of the patients and healthy control subjects were compared. The changes in microbiota composition in both habitats, their correlations and associations with IGF-1 were statistically observed using machine learning models. Results Fifteen patients with newly diagnosed acromegaly without comorbidities and 15 healthy controls were included in the study. There was good agreement between fecal and oral microbiota in patients with acromegaly (p = 0.03). Oral microbiota diversity was significantly increased in patients with acromegaly (p < 0.01). In the fecal microbiota, the Firmicutes/Bacteroidetes ratio was lower in patients with acromegaly than in healthy controls (p = 0.011). Application of the transfer learned model to the pattern of microbiota allowed us to identify the patients with acromegaly with perfect accuracy. Conclusions Patients with acromegaly have their own oral and gut microbiota even if they do not have acromegaly-related complications. Moreover, the excess IGF-1 levels could be correctly predicted based on the pattern of the microbiome.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa [TSA-2020-34925]
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa. Project Number TSA-2020-34925.
dc.identifier.doi10.1007/s11102-022-01223-1
dc.identifier.endpage530
dc.identifier.issn1386-341X
dc.identifier.issn1573-7403
dc.identifier.issue3en_US
dc.identifier.pmid35467272
dc.identifier.scopus2-s2.0-85128859257
dc.identifier.scopusqualityQ2
dc.identifier.startpage520
dc.identifier.urihttps://doi.org/10.1007/s11102-022-01223-1
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10838
dc.identifier.volume25
dc.identifier.wosWOS:000787105100002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorElbüken, Gülşah
dc.institutionauthorZuhur, Sayid Shafi
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPituitary
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcromegaly
dc.subjectMicrobiome
dc.subjectMicrobiota
dc.subjectIgf-1
dc.subjectAnterior Pituitary
dc.subjectEpidemiology
dc.subjectPathogenesis
dc.subjectGrowth
dc.titleAcromegaly is associated with a distinct oral and gut microbiota
dc.typeArticle

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