Protective effects of melatonin receptor agonists on endotoxin- induced uveitis in rats

Basit Öğe Kaydı
dc.contributor.authorYüksel, Tuğba Nurcan
dc.contributor.authorYayla, Muhammed
dc.contributor.authorKöşe, Duygu
dc.contributor.authorHalıcı, Zekai
dc.contributor.authorBozkurt, Erdinç
dc.contributor.authorToktay, Erdem
dc.date.accessioned2023-05-06T17:23:35Z
dc.date.available2023-05-06T17:23:35Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractObjective(s): Melatonin has an important role in regulating a variety of physiological functions of the body. We investigated the protective effects of Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis (EIU) in rats. Materials and Methods: 70 rats were randomly divided into fourteen groups. Healthy group normal saline, (IP), Uveitis group (200 pg/kg lipopolysaccharide (LPS), SC), DEX group (200 pg/kg LPS plus 1 mg/kg dexamethasone, IP), AGO20 group received 200 pg/kg LPS plus 20 mg/kg AGO, AGO40 group received 200 pg/kg LPS plus 40 mg/kg AGO, RAME2 group received 200 pg/kg LPS plus 2 mg/kg RAME, and group RAME4 received 200 pg/kg LPS plus 4 mg/kg RAME. Each group had two subgroups: the 3rd and 24th hour. The eye tissues were collected and investigated biomicroscopically (clinical manifestations and scoring, molecularly(qRT-PCR analyses of Tumor Necrosis Factor-alpha (TNF-alpha), vascular endothelial growth factor(VEGF), and Caspase 3 and Caspase 9 mRNA expression), biochemically (Superoxide dismutase activity, Glutathione, and Malondialdehyde levels) and histopathologically (staining with Harris Hematoxylin and Eosin Y). Results: Melatonin receptor agonist treatment reduced the clinical score count of ocular inflammation in the uveitic rats. TNF-alpha, VEGF, Caspase 9, and Caspase 3 levels markedly decreased in the uveitic rats. Melatonin receptor agonists significantly ameliorated fixed changes in GSH, SOD, and MDA levels. Melatonin receptor agonists also ameliorated histopathological injury in eye tissues associated with uveitis. Conclusion: Melatonin receptor agonists ameliorated the inflammatory response in EIU. These findings suggest that melatonin receptor agonists may represent a potential novel therapeutic drug for uveitis treatment.
dc.identifier.doi10.22038/IJBMS.2023.67297.14749
dc.identifier.endpage548
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85153195136
dc.identifier.scopusqualityQ2
dc.identifier.startpage540
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2023.67297.14749
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12172
dc.identifier.volume26
dc.identifier.wosWOS:000953843300007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYüksel, Tuğba Nurcan
dc.language.isoen
dc.publisherMashhad Univ Med Sciences
dc.relation.ispartofIranian Journal Of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLipopolysaccharides
dc.subjectMelatonin
dc.subjectOxidative stress
dc.subjectUveitis
dc.subjectRats
dc.subjectEndothelial Growth-Factor
dc.subjectInflammation
dc.subjectApoptosis
dc.subjectModel
dc.subjectRamelteon
dc.subjectCancer
dc.subjectAssay
dc.subjectRisk
dc.titleProtective effects of melatonin receptor agonists on endotoxin- induced uveitis in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
12172.pdf
Boyut:
989.73 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu