Rapamycin Improves Vascular Remodelling in a Controlled Rat Model of Monocrotaline-Induced Pulmonary Hypertension

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dc.contributor.authorŞengül, A.
dc.contributor.authorVural, C.
dc.contributor.authorArkan, S.
dc.contributor.authorÖzer, C.
dc.contributor.authorBayrak, B. Y.
dc.contributor.authorTaş, A.
dc.contributor.authorAltıntaş, Nejat
dc.date.accessioned2023-05-06T17:23:32Z
dc.date.available2023-05-06T17:23:32Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Pulmonary arterial hypertension (PAH) is a serious disease characterized by the progressive elevation of the pulmonary arterial resistance, leading to the right ventricular failure and death. Objective: To evaluate the effect of rapamycin (RAPA), a potent cell-cycle inhibitor, on exercise capacity, right ventricular hypertrophy and pulmonary vascular remodelling on rats. Methods: A total of 39 nine-week-old male Wistar rats (160-240 g) were divided into three groups: the control (n = 10), PAH control (n = 15) and PAH-RAPA (n = 14) groups. On the 1st day, 60 mg/kg monocrotaline was injected intraperitoneally to induce PAH in the PAH control group and PAH-RAPA groups. On the 21st day, 3 mg/kg/day RAPA was started orally, and the animals were followed for 35 days. On the 35th day, the exercise capacity of the rats was analysed through a modified forced swimming test. After measuring their right ventricular systolic pressure using an open-chest method, their hearts and lungs were excised and analysed histopathologically for right ventricular hypertrophy and pulmonary vascular remodelling. Results: Rapamycin treatment provided limited and insignificant improvements in exercise capacity, right ventricular systolic pressure and right ventricular hypertrophy of the rats. However, there was significant recovery in the rats' pulmonary artery muscular layer thickness with the RAPA treatment (p < 0.049). On the 35th day, the mortality rate was 0% in the control group, 53.1% in the PAH control group and 42.9% in the PAH-RAPA group. No statistically significant decrease was observed in their mortality rates with the RAPA treatment (p > 0.16); however, a significant recovery was noted in terms of the rats 'median life span (p < 0.006). Conclusion: Pulmonary artificial hypertension is a progressive disease that is not curable with current therapies. Rapamycin may have the potential to reverse vascular remodelling and prolong life expectancy in cases ofpulmonary hypertension.
dc.identifier.doi10.7727/wimj.2015.222
dc.identifier.endpage644
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85164945410
dc.identifier.scopusqualityQ4
dc.identifier.startpage638
dc.identifier.urihttps://doi.org/10.7727/wimj.2015.222
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12126
dc.identifier.volume69
dc.identifier.wosWOS:000916510100009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAltıntaş, Nejat
dc.language.isoen
dc.publisherUniv West Indies Faculty Medical Sciences
dc.relation.ispartofWest Indian Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLife expectancy
dc.subjectpulmonary hypertension
dc.subjectrapamycin
dc.subjectvascular remodelling
dc.subjectArterial-Hypertension
dc.subjectCell Proliferation
dc.subjectMtor
dc.subjectEverolimus
dc.subjectExpression
dc.subjectInhibitors
dc.subjectSirolimus
dc.subjectFibrosis
dc.subjectTherapy
dc.subjectTarget
dc.titleRapamycin Improves Vascular Remodelling in a Controlled Rat Model of Monocrotaline-Induced Pulmonary Hypertension
dc.typeArticle

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