The effects of thymoquinone and curcumin on the thyroid in rats with subacute fluoride poisoning

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dc.contributor.authorArslan, S.
dc.contributor.authorInan, S.
dc.contributor.authorYenilmez, K.
dc.date.accessioned2024-10-29T17:43:40Z
dc.date.available2024-10-29T17:43:40Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThe purpose of this study was to determine the protective effect of thymoquinone (TQ), curcumin (CUR), and a TQ+CUR combination on thyroid hormones and histopathology in an experimentally-induced, subacute, sodium fluoride (NaF) toxicity rat model. Control, sham, and test groups (NaF, NaF+TQ, NaF+CUR, and NaF+TQ+CUR) were established in the study. At the end of the experiment, test groups had higher urine fluoride concentrations. Triiodothyronine (T3), thyroxin (T4), free triiodothyronine (FT3), and free thyroxin (FT4) levels decreased substantially, and thyroid-stimulating hormone (TSH) levels increased substantially when the control and test groups were compared. T3 and T4 decreased and TSH increased in the NaF group compared to the NaF+TQ, NaF+CUR, and NaF+TQ+CUR groups. Microscopic study of thyroid tissues revealed that the test groups showed statistically significant differences from the control group in terms of follicular degeneration (FD), decrease in colloidal fluid (DCF), fibrosis, atypical follicle epithelium (AFE), and mononuclear cell infiltration (MCI). When the NaF group and other test groups were compared, statistical significance was observed in the histopathological scoring of DCF, AFE, and MCI in the NaF+TQ group; FD, DCF, AFE, and MCI in the NaF+CUR group; and DCF, AFE, and MCI in the NaF+TQ+CUR group. Fluoride toxicity, therefore, caused problems with the thyroid and hormones. The study revealed that TQ and CUR combined with fluoride could not normalize the thyroid gland and thyroid hormones but could alleviate thyroid gland damage and provide a partial improvement in thyroid hormone levels. © 2023, South African Journal for Animal Sciences. All rights reserved.
dc.description.sponsorshipTekirdağ Namık Kemal Üniversitesi, TNKU, (21.300, NKUBAP.10)
dc.identifier.doi10.4314/sajas.v53i5.11
dc.identifier.endpage727
dc.identifier.issn0375-1589
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85175375207
dc.identifier.scopusqualityQ3
dc.identifier.startpage720
dc.identifier.urihttps://doi.org/10.4314/sajas.v53i5.11
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12552
dc.identifier.volume53
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSouth African Journal for Animal Sciences
dc.relation.ispartofSouth African Journal of Animal Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectfluoride
dc.subjectrat
dc.subjectthyroid
dc.titleThe effects of thymoquinone and curcumin on the thyroid in rats with subacute fluoride poisoning
dc.typeArticle

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