Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

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dc.authorid0000-0001-7213-9624
dc.authorid0000-0001-7213-9624
dc.authorscopusid56291092000
dc.authorscopusid56470644300
dc.authorscopusid56290776600
dc.authorscopusid23968920100
dc.authorscopusid56406174400
dc.authorscopusid15727384300
dc.authorscopusid8525219800
dc.authorwosiderman, hande/AAP-6507-2021
dc.authorwosiderman, hande/AAZ-7697-2021
dc.contributor.authorBoyuk, Banu
dc.contributor.authorDeğirmencioğlu, Şerife
dc.contributor.authorAtalay, Hande
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAcar, Ayşe
dc.contributor.authorÇelebi, Aslan
dc.contributor.authorŞimşek, Çağlar
dc.date.accessioned2022-05-11T14:42:05Z
dc.date.available2022-05-11T14:42:05Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground and Aim. Studies have suggested that brain-derived neurotrophic factor (BDNF) plays a role in glucose and lipid metabolism and inflammation. The aim of this study was to evaluate the relationship between serum BDNF levels and various metabolic parameters and inflammatory markers in patients with type 2 diabetes mellitus (T2DM). Materials and Methods. The study included 88 T2DM patients and 33 healthy controls. Fasting blood samples were obtained from the patients and the control group. The serum levels of BDNF were measured with an ELISA kit. The current paper introduces a receiver-operating characteristic (ROC) generalization curve to identify cut-off for the BDNF values in type 2 diabetes patients. Results. The serum levels of BDNF were significantly higher in T2DM patients than in the healthy controls (206.81 +/- 107.32 pg/mL versus 130.84 +/- 59.81 pg/mL; P < 0.001). They showed a positive correlation with the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.28; P < 0.05), the triglyceride level (r = 0.265; P < 0.05), and white blood cell (WBC) count (r = 0.35; P < 0.001). In logistic regression analysis, age (P < 0.05), body mass index (BMI) (P < 0.05), C-reactive protein (CRP) (P < 0.05), and BDNF (P < 0.01) were independently associated with T2DM. In ROC curve analysis, BDNF cut-off was 137. Conclusion. The serum BDNF level was higher in patients with T2DM. The BDNF had a cut-off value of 137. The findings suggest that BDNF may contribute to glucose and lipid metabolism and inflammation.
dc.identifier.doi10.1155/2014/978143
dc.identifier.endpage6
dc.identifier.issn2314-6745
dc.identifier.issn2314-6753
dc.identifier.pmid25587547
dc.identifier.scopus2-s2.0-84920527763
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1155/2014/978143
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9210
dc.identifier.volume2014
dc.identifier.wosWOS:000347333300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüzel, Savaş
dc.institutionauthorAcar, Ayşe
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofJournal of Diabetes Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInsulin-Resistance
dc.subjectFactor Bdnf
dc.subjectGlucose-Metabolism
dc.subjectMice
dc.subjectNgf
dc.subjectExpression
dc.subjectPhysiology
dc.subjectDiseases
dc.subjectObesity
dc.subjectCells
dc.titleRelationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus
dc.typeArticle

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