Quercetin Inhibits Heart Injury in Lipopolysaccharide-induced Endotoxemic Model by Suppressing the Effects of Reactive Oxygen Species

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dc.authorid0000-0002-2270-2965
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorAktaş, Cevat
dc.contributor.authorÇağlar, Veli
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:07:32Z
dc.date.available2022-05-11T14:07:32Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractOBJECTIVE: To examine the histopathological and biochemical effects of quercetin (QE), which has antioxidant properties, on damaged heart muscle in a lipopolysaccharide (LPS)-induced endotoxemia model in rats. STUDY DESIGN: Rats were divided into 4 groups: Control, QE, LPS, and LPS+QE. Escherichia coli LPS, 10 mg/kg, was administered intravenously to induce endotoxemia in the LPS and LPS+QE groups. A single dose of 50 mg/kg QE was administered intraperitoneally to QE groups 30 minutes prior to administering LPS. The rats were sacrificed at the end of the 6-hour period following LPS application. RESULTS: It was observed in histopathological evaluations that the heart tissue injury and inflammation in the LPS groups were higher than those of the LPS+QE group, and that QE partially prevented damage caused by endotoxemia. Rats in the LPS groups demonstrated significantly increased tissue malondialdehyde levels and significantly decreased enzymatic antioxidants superoxide dismutase and catalase in the cardiac tissue. It was observed that QE treatment increased the superoxide dismutase and catalase enzyme levels that decreased after LPS. CONCLUSION: QE with antioxidant properties prevented heart damage caused by free oxygen radicals that occurred after LPS-induced endotoxemia and increased the antioxidant defense system.
dc.identifier.endpage188
dc.identifier.issn0884-6812
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84975462305
dc.identifier.scopusqualityN/A
dc.identifier.startpage183
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5139
dc.identifier.volume38
dc.identifier.wosWOS:000399656100006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorDoğan, Mustafa
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorAktaş, Cevat
dc.institutionauthorÇağlar, Veli
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherSci Printers & Publ Inc
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantioxidant effect
dc.subjectantioxidants
dc.subjectendotoxemia
dc.subjectendotoxins
dc.subjectflavonol
dc.subjectheart
dc.subjectlipoglycans
dc.subjectlipopolysaccharides
dc.subjectLPS
dc.subjectoxidative damage
dc.subjectoxidative stress
dc.subjectquercetin
dc.subjectsepsis
dc.subjectseptic shock
dc.subjectshock
dc.subjectendotoxic
dc.subjecttoxemia
dc.subjectAcute Lung Injury
dc.subjectOxidative Stress
dc.subjectSevere Sepsis
dc.subjectSeptic Shock
dc.subjectDysfunction
dc.subjectBioavailability
dc.subjectInflammation
dc.subjectMechanisms
dc.subjectExpression
dc.subjectMortality
dc.titleQuercetin Inhibits Heart Injury in Lipopolysaccharide-induced Endotoxemic Model by Suppressing the Effects of Reactive Oxygen Species
dc.typeArticle

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