Effect of Urtica Dioica against Doxorubicin-Induced Cardiotoxicity in Rats through Suppression of Histological Damage, Oxidative Stress and Lipid Peroxidation

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dc.authorscopusid36023238400
dc.authorscopusid55134339900
dc.authorscopusid55515412500
dc.authorscopusid56816914100
dc.authorscopusid24436194200
dc.authorscopusid7006356462
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidsener, umit/AAZ-7728-2020
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorDönmez, Yeliz Bozdemir
dc.contributor.authorŞener, Ümit
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorAktaş, Cevat
dc.contributor.authorKanter, Mehmet
dc.date.accessioned2022-05-11T14:14:00Z
dc.date.available2022-05-11T14:14:00Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractObjective: Doxorubicin (DOX) is a highly effective anti-cancer drug with limited clinical use due to its serious cardiotoxicity. Urtica dioica L. seeds (UD), have been widely used in folk medicine, particularly in the therapy for advanced cancer patients, possesses a potent anti-oxidant properties. The goal of present study was to investigate the cardioprotective effects of UD on DOX-induced cardiotoxicity. Method: The rats in the UD treated group were given intraperitoneally 2 ml/kg UD. To induce cardiotoxicity, 30 mg/kg DOX was injected intraperitoneally by a single dose and the rats were sacrificed after 48 h. Results: The present study revealed for the first time a protective role of UD against DOX-induced cardiotoxicity. UD therapy significantly protected against DOX-induced myocardial damage which was characterized by conduction abnormalities, vacuolization, inflammatory cell infiltration, hemorrhages, and myofibrillar disarrangement. As indicators of oxidative stress, DOX caused significantly increase lipid peroxidation and reduction in activities of antioxidant enzymes; superoxide dismutase, glutathione peroxidase, and catalase. UD treatment significantly attenuated DOX-induced oxidative injury. Conclusion: The present study showed that UD might be a suitable cardioprotector against toxic effects of DOX.
dc.identifier.doi10.15197/ejgm.1567
dc.identifier.endpage144
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84964049286
dc.identifier.scopusqualityN/A
dc.identifier.startpage139
dc.identifier.urihttps://doi.org/10.15197/ejgm.1567
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5742
dc.identifier.volume13
dc.identifier.wosWOS:000392237800009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorDönmez, Yeliz Bozdemir
dc.institutionauthorErboğa, Zeynep Fidanol
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.publisherModestum Ltd
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDoxorubicin
dc.subjecturtica dioica
dc.subjectcardiotoxicity
dc.subjectoxidative stress
dc.subjectrat
dc.subjectCardiac Toxicity
dc.subjectAntioxidants
dc.subjectMechanisms
dc.subjectApoptosis
dc.subjectProtects
dc.subjectFibrosis
dc.subjectDrugs
dc.subjectHeart
dc.titleEffect of Urtica Dioica against Doxorubicin-Induced Cardiotoxicity in Rats through Suppression of Histological Damage, Oxidative Stress and Lipid Peroxidation
dc.title.alternativeUrtica dioica'nın sıçanlarda doksorubisine bağlı kardiyotosisitede histolojik hasar, oksidatif stress ve lipid peroksidasyon bakılayıcı etkileri]
dc.typeArticle

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