Evaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination

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dc.authorscopusid23986422400
dc.authorscopusid56599872000
dc.authorscopusid24075279000
dc.authorscopusid6506061779
dc.authorscopusid23968920100
dc.authorscopusid14071985300
dc.authorscopusid24366279300
dc.contributor.authorTaşdemir, Nicel
dc.contributor.authorŞahin, Aziz
dc.contributor.authorÇelik, Cem
dc.contributor.authorAbalı, Remzi
dc.contributor.authorGüzel, Savaş
dc.contributor.authorUzunlar, O.
dc.contributor.authorGülerman, C.
dc.date.accessioned2022-05-11T14:14:02Z
dc.date.available2022-05-11T14:14:02Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractIntroduction: The implantation of embryo is one of the crucial steps of a successful pregnancy. The foetus should be protected from maternal immune system, for the appropriate implantation and modification in maternal immunity is crucial. We investigated high-sensitivity C-reactive protein (hs CRP), which is an indicator of low-grade inflammation and Cp10 that has immunosuppressant and growth-promoting capabilities at embryo levels in ovulation induction and intra-uterine insemination (IUI) applied in infertile women. The ovulation induction was maintained by clomiphene citrate or gonadotropins for 42 infertile patients. After successful ovulation induction, IUI was carried out. The blood samples were taken 2 and 8 days after IUI to evaluate Cp10 and hs CRP levels. The pregnant and non-pregnant groups' results were analyzed. The Cp10 levels 8 days after IUI were higher in pregnant group, whereas there was no difference for the 2 days after levels between pregnant and non-pregnant group. The hs CRP levels were similar for both 2nd and 8th days when we compared pregnant and non-pregnant groups. The Cp10 levels increased from day 2 to day 8 in pregnant group. In contrast, the Cp10 levels decreased in non-pregnant group. The change in hs CRP levels from day 2 to day 8 was not significant in pregnant and non-pregnant groups. The Cp10 levels were higher in early phases of fertilisation and elevated through the preceding days of conception in pregnant patients, while it decreased in non-pregnant patients with failed cycles.
dc.description.sponsorshipNamik Kemal University, Scientific Research Project ProgrammeNamik Kemal University [NKUBAP.00.20.AR.11.02]
dc.description.sponsorshipThe study was funded by Namik Kemal University, Scientific Research Project Programme. (NKUBAP.00.20.AR.11.02)
dc.identifier.doi10.3109/01443615.2014.991297
dc.identifier.endpage710
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue7en_US
dc.identifier.pmid25543530
dc.identifier.scopus2-s2.0-84944161742
dc.identifier.scopusqualityQ3
dc.identifier.startpage707
dc.identifier.urihttps://doi.org/10.3109/01443615.2014.991297
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5752
dc.identifier.volume35
dc.identifier.wosWOS:000369868100013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTaşdemir, Nicel
dc.institutionauthorÇelik, Cem
dc.institutionauthorAbalı, Remzi
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Obstetrics and Gynaecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchaperonin 10
dc.subjecthigh-sensitivity C-reactive protein
dc.subjectinfertility
dc.subjectintra-uterine insemination
dc.subjectimplantation
dc.subjectovulation induction
dc.subjectEarly-Pregnancy Factor
dc.subjectFactor Epf
dc.subjectAntibodies
dc.subjectSerum
dc.titleEvaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination
dc.typeArticle

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