Effect of harmane, an endogenous beta-carboline, on learning and memory in rats

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dc.authorid0000-0001-7341-4907
dc.authorid0000-0003-0895-3490
dc.authorid0000-0001-5848-3680
dc.authorid0000-0003-1105-7646
dc.authorscopusid35331721100
dc.authorscopusid7003362092
dc.authorscopusid11440747800
dc.authorscopusid7201404044
dc.authorscopusid10638814800
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidUtkan, Tijen/G-2398-2018
dc.authorwosidARICIOGLU, FEYZA/AAR-5704-2020
dc.authorwosidCelikyurt, Ipek Komsuoglu/F-7363-2018
dc.authorwosidAricioglu, Feyza/ABI-4003-2020
dc.contributor.authorÇelikyurt, İpek Komşuoğlu
dc.contributor.authorUtkan, Tijen
dc.contributor.authorGöçmez, Semil Selcen
dc.contributor.authorHudson, Alan
dc.contributor.authorArıcıoğlu, Feyza
dc.date.accessioned2022-05-11T14:41:10Z
dc.date.available2022-05-11T14:41:10Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractOur aim was to investigate the effects of acute harmane administration upon learning and memory performance of rats using the three-panel runway paradigm and passive avoidance test. Male rats received harmane (2.5, 5, and 7.5 mg/kg, i.p.) or saline 30 min. before each session of experiments. In the three panel runway paradigm, harmane did not affect the number of errors and latency in reference memory. The effect of harmane on the errors of working memory was significantly higher following the doses of 5 mg/kg and 7.5 mg/kg. The latency was changed significantly at only 7.5 mg/kg in comparison to control group. Animals were given pre-training injection of harmane in the passive avoidance test in order to determine the learning function. Harmane treatment decreased the retention latency significantly and dose dependently, which indicates an impairment in learning. In this study, harmane impaired working memory in three panel runway test and learning in passive avoidance test. As an endogenous bioactive molecule, harmane might have a critical role in the modulation of learning and memory functions. (c) 2012 Elsevier Inc. All rights reserved.
dc.description.sponsorshipResearch Foundation of the Kocaeli UniversityKocaeli University [200439]
dc.description.sponsorshipThe present study was supported by Research Foundation of the Kocaeli University (project number: 200439) and presented at EPHAR 2008 Congress, Manchester, UK, 13-17 July 2008.
dc.identifier.doi10.1016/j.pbb.2012.10.011
dc.identifier.endpage671
dc.identifier.issn0091-3057
dc.identifier.issue3en_US
dc.identifier.pmid23107644
dc.identifier.scopus2-s2.0-84870291381
dc.identifier.scopusqualityQ1
dc.identifier.startpage666
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2012.10.011
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9093
dc.identifier.volume103
dc.identifier.wosWOS:000314792100032
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöçmez, Semil Selcen
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHarmane
dc.subjectLearning
dc.subjectMemory
dc.subjectThree panel runway
dc.subjectPassive avoidance
dc.subjectRats
dc.subjectPassive-Avoidance Test
dc.subjectWorking-Memory
dc.subjectBenzodiazepine Receptors
dc.subjectInhibitory Avoidance
dc.subjectCholinergic System
dc.subjectInduced Amnesia
dc.subjectBrain
dc.subjectMice
dc.subjectAcquisition
dc.subjectInvolvement
dc.titleEffect of harmane, an endogenous beta-carboline, on learning and memory in rats
dc.typeArticle

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