Prospective comparison of the value of CARG, G8, and VES-13 toxicity tools in predicting chemotherapy-related toxicity in older Turkish patients with cancer

Basit Öğe Kaydı
dc.authoridCavdar, Eyyup/0000-0001-5885-3047
dc.contributor.authorÇavdar, Eyyüp
dc.contributor.authorİriağaç, Yakup
dc.contributor.authorKaraboyun, Kubilay
dc.contributor.authorAvcı, Okan
dc.contributor.authorŞeber, Erdoğan Selçuk
dc.date.accessioned2023-04-20T08:01:18Z
dc.date.available2023-04-20T08:01:18Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: In older patients with cancer, it is very important to choose the appropriate treatment because they are at high risk for chemotherapy toxicity. Our study investigated characteristics of Cancer and Aging Research Group (CARG), Geriatric 8 (G8), and Vulnerable Elders Survey (VES-13) screening tools for predicting chemotherapy-related toxicity (CRT) prospectively.Materials and methods: 208 patients aged >= 65 years old for whom chemotherapy was planned to treat non -haematological cancer between February 2021-September 2021 were included in the study. The CARG, G8, and VES-13 toxicity tools were completed by the oncologist through face-to-face interviews before starting the first chemotherapy treatment. CRTs during chemotherapy were evaluated according to the National Cancer Insti-tute's Common Terminology Criteria for Adverse Events v4.03. Logistic regression models, the area under the re-ceiver operating characteristic curve (ROC-AUC), and correlation analyses were used for comparing questionnaires.Results: Median age was 70.4 (range 65-86) years. Of the participants, 103 (49.5%) participants experienced grade 3-5 CRT (32.2% haematological, 28.4% non-haematological) during chemotherapy. ROC-AUC value of CARG was determined as 0.827 (95% CI [confidence interval]: 0.77-0.88, p < 0.001), it was determined as 0.744 (95% CI: 0.68-0.81, p < 0.001) for G8 and 0.726 (95% CI: 0.66-0.80, p < 0.001) for VES-13. In the univariate regression analysis, CARG (OR [odds ratio] = 13.57, 95% CI: 6.0-30.72, p < 0.001), G8 (OR = 3.19, 95% CI: 1.62-6.29, p = 0.001), and VES-13 (OR = 9.5, 95% CI: 5.01-17.89, p < 0.001) were found to be predictive for CRT. The multivariate analysis (included stage, Eastern Cooperative Oncology Group [ECOG] performance status, presence of comorbid disease, platinum-based treatment regimen, taxane-based treatment regimen, CARG, VES-13, G8) showed that CARG (OR =12.08, 95% CI: 5.11-28.56, p < 0.001), VES-13 (OR =10.06, 95% CI: 4.92-22.98, p < 0.001), and G8 (OR = 2.20, 95% CI: 1.04-4.69, p = 0.040) screening tools were strong predictors for CRT. The CARG and VES-13 questionnaires were predictive for reducing the initial treatment dose (p = 0.004, p = 0.004, respectively), interruption of treatment (p < 0.001, p < 0.001, respectively), discontinuing treatment (p = 0.002, p = 0.002, respectively), and unexpected hospitalisation (p = 0.012, p = 0.003, respectively).Conclusions: We showed that all three CARG, G8, and VES-13 questionnaires are helpful tools in the decision -making process for ideal chemotherapy to predict severe CRT; however, CARG and VES-13 questionnaires appear more useful in daily oncology practice than the G8 questionnaire. (c) 2022 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.jgo.2022.03.004
dc.identifier.endpage827
dc.identifier.issn1879-4068
dc.identifier.issn1879-4076
dc.identifier.issue6en_US
dc.identifier.pmid35361561
dc.identifier.scopus2-s2.0-85127304494
dc.identifier.scopusqualityQ2
dc.identifier.startpage821
dc.identifier.urihttps://doi.org/10.1016/j.jgo.2022.03.004
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10862
dc.identifier.volume13
dc.identifier.wosWOS:000829687600008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇavdar, Eyyüp
dc.institutionauthorİriağaç, Yakup
dc.institutionauthorKaraboyun, Kubilay
dc.institutionauthorAvcı, Okan
dc.institutionauthorŞeber, Erdoğan Selçuk
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Geriatric Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOlder Patients With Cancer
dc.subjectChemotherapy
dc.subjectToxicity
dc.subjectCarg
dc.subjectVes-13
dc.subjectC8
dc.subjectGeriatric Assessment
dc.subjectInternational-Society
dc.subjectBreast-Cancer
dc.subjectAdults
dc.subjectComorbidity
dc.titleProspective comparison of the value of CARG, G8, and VES-13 toxicity tools in predicting chemotherapy-related toxicity in older Turkish patients with cancer
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
10866.pdf
Boyut:
622.07 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu