New Prognostic Parameter of West Nile Virus: Platelet Distribution Width

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dc.authoridGURKOK BUDAK, GOKCEN/0000-0002-6317-7685
dc.authoridSIMSEK, ADEM/0000-0001-5992-3502
dc.authoridKARABAY, OGUZ/0000-0003-1514-1685
dc.authoridAlan, Sevgi/0000-0002-2810-2063
dc.authoridCALICA UTKU, AYLIN/0000-0002-9302-5842
dc.authoriduzun, cem/0000-0001-5675-829X
dc.authoridGENC, AHMED CIHAD/0000-0002-7725-707X
dc.contributor.authorGenc, Ahmed Cihad
dc.contributor.authorKarabay, Oguz
dc.contributor.authorGuclu, Ertugrul
dc.contributor.authorUtku, Aylin Calica
dc.contributor.authorVatan, Asli
dc.contributor.authorTuna, Nazan
dc.contributor.authorBudak, Gokcen
dc.date.accessioned2024-10-29T17:58:38Z
dc.date.available2024-10-29T17:58:38Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractBackground: West Nile virus (WNV) infection is a viral disease caused by arboviruses. It can cause epidemics of febrile diseases and meningoencephalitis, especially at the end of the summer season. In this study, we aimed to determine the risk factors of WNV encephalitis with a case-control study of the patients followed in our clinic. Materials and Methods: Among the patients who applied to our hospital with sudden onset fever, headache, myalgia, nausea, vomiting, maculopapular rash, viral meningitis, or encephalitis findings in late summer and early autumn, those diagnosed with positive WNV PCR and antibody tests were defined as WNV cases. In the same date range, patients with clinically compatible but negative serological and PCR tests for WNV in our hospital were considered as the control group. Results: WNV infection was diagnosed in 26 of 48 patients who were examined with a preliminary diagnosis of WNV infection, and the other 22 patients were considered as the control group. A statistically significant difference was found between the two groups in C-reactive protein, procalcitonin, 1-h erythrocyte sedimentation rate, alkaline phosphatase, platelet, and platelet distribution width (PDW). PDW > 17.85% indicated WNV infection with 82% sensitivity and 91% specificity. PDW percentage > 17.85 increased the risk of WNV infection by 6.1 times. The power of the study was calculated as 83%. Conclusion: The most common findings in WNV cases were fever and confusion. WNV infection should be considered in the differential diagnosis in patients with fever and confusion in September and October in settlements on the migration route of birds. The percentage of PDW in whole blood examination can guide the differential diagnosis of WNV cases.
dc.description.sponsorshipInfection Control Committee; Sakarya Training and Research Hospital
dc.description.sponsorshipWe thank the Sakarya Training and Research Hospital and the Infection Control Committee for their support in this research.
dc.identifier.doi10.1089/vbz.2023.0056
dc.identifier.endpage171
dc.identifier.issn1530-3667
dc.identifier.issn1557-7759
dc.identifier.issue3en_US
dc.identifier.pmid37824783
dc.identifier.scopus2-s2.0-85174539765
dc.identifier.scopusqualityQ3
dc.identifier.startpage166
dc.identifier.urihttps://doi.org/10.1089/vbz.2023.0056
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14429
dc.identifier.volume24
dc.identifier.wosWOS:001158529200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofVector-Borne and Zoonotic Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectWest Nile virus
dc.subjectarbovirus
dc.subjectplatelet distribution width
dc.titleNew Prognostic Parameter of West Nile Virus: Platelet Distribution Width
dc.typeArticle

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