The Effect of Curcumin on an Animal Intestinal Ischemia/Reperfusion Model for Bacterial Translocation and Inflammatory Response

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dc.authorid0000-0003-2006-9198
dc.authorid0000-0001-6758-7289
dc.authorid0000-0001-9111-2734
dc.authorscopusid35410250800
dc.authorscopusid35791793300
dc.authorscopusid55624501100
dc.authorscopusid17433815200
dc.authorscopusid56462631800
dc.authorscopusid54082781700
dc.authorscopusid56669618000
dc.authorwosidSözen, Selim/ABA-6337-2020
dc.authorwosidAZİRET, MEHMET/I-5483-2014
dc.authorwosidCetinkunar, Suleyman/AFP-2813-2022
dc.contributor.authorSözen, Selim
dc.contributor.authorAziret, Mehmet
dc.contributor.authorBali, İlhan
dc.contributor.authorEmir, Seyfi
dc.contributor.authorÜlgen, Yiğit
dc.contributor.authorBinnetoğlu, Kenan
dc.contributor.authorÇetinkunar, Süleyman
dc.date.accessioned2022-05-11T14:34:56Z
dc.date.available2022-05-11T14:34:56Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractIschemia/reperfusion (IR) injury of the intestine is a major problem in abdominal pathological condition and is associated with a high morbidity and mortality. The purpose of the study is to investigate the effects of curcumin on the bacterial translocation incidence and inflammatory response in rats submitted to bowel ischemia reperfusion injury. Thirty-two Wistar albino rats with a weight of 200 to 250 g were used in the study. They were randomly divided into 3 groups (n = 10 for each group): sham only operated group(group I); IR group (group II); and IR + curcumin treatment group (group III). Curcumin (curcumin from Curcuma longa) 20 mg/kg/day was given orally to the curcumin group. All animals were given 109 E. Coli by orogastric intubation 12 hours before sampling. Seventy-two hours after the first operation, mesenteric lymph node and blood samples were obtained and cultured. Blood samples of 2 mL were obtained for a polymerase chain reaction study. A piece of terminal ileum was also sampled for histopathologic examination. Mesenteric lymph node and blood cultures of all control animals were positive for microbiological growth, and polymerase chain reaction results were positive in seven of the eight rats. Histopathologically, edema, vasodilatation and inflammatory cell infiltration were found to be less in the other groups in comparison to the control group. Curcumin reduced bacterial translocation in blood, hepatocellular damage, and plasma cytokine levels. Curcumin reduced the incidence of bacterial translocation in intestinal I/R. rats. These results suggest that Curcumin would be clinically useful in the treatment of intestinal I/R injury.
dc.identifier.doi10.9738/INTSURG-D-15-00004.1
dc.identifier.endpage1359
dc.identifier.issn0020-8868
dc.identifier.issue45637en_US
dc.identifier.scopus2-s2.0-84991698854
dc.identifier.scopusqualityQ4
dc.identifier.startpage1352
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-15-00004.1
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8146
dc.identifier.volume100
dc.identifier.wosWOS:000212851100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSözen, Selim
dc.institutionauthorBali, İlhan
dc.institutionauthorEmir, Seyfi
dc.language.isoen
dc.publisherInt College Of Surgeons
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBacterial translocation
dc.subjectCurcumin
dc.subjectIschemia/reperfusion injury
dc.subjectIntestine
dc.titleThe Effect of Curcumin on an Animal Intestinal Ischemia/Reperfusion Model for Bacterial Translocation and Inflammatory Response
dc.typeArticle

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