The role of NMDA glutamate receptors in lung injury caused by chronic long-term intermittent hypobaric hypoxia

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dc.contributor.authorYaman, Muhittin Onur
dc.contributor.authorSönmez, O. F.
dc.contributor.authorEkiz-Yılmaz, T.
dc.contributor.authorSönmez, D.
dc.contributor.authorMeydanlı, E. E. G.
dc.contributor.authorGüner, İbrahim
dc.contributor.authorŞahin, G.
dc.date.accessioned2023-05-06T17:23:35Z
dc.date.available2023-05-06T17:23:35Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractChronic intermittent hypoxia (CIH), a component of sleep apnea-hypopnea syndrome, is suggested to cause damage to lung tissue, and the role of glutamate is not well studied. We used a chronic long-term intermittent hypobaric hypoxia (CLTIHH) model of rats to find out if such procedure causes lung injury and the potential effect of N-methyl-D-aspartate receptors (NMDARs) by using receptor antagonist MK-801 (dizocilpine). Thirty-two rats were placed into four groups; a control and three CLTIHH groups where rats were placed into a low-pressure chamber set to 430 mmHg for 5 h/day, 5 days/week, for 5 weeks. Only one group received MK-801 (0.3 mg/kg, ip) daily. We evaluated tumor necrosis factor (TNF)-a, interleukin (IL)-6, IL-10, and nuclear factor (NF)-kB for the inflammatory process, superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPX), total antioxidant status (TAS), and total oxidant status (TOS) for oxidative stress, and caspase-9 levels. Blood plasma, bronchoalveolar fluid (BALF), and lung tissue extracts were evaluated. Both oxidant and inflammatory parameters were significantly increased in all the mediums of the CLTIHH groups except the group that received MK-801. Significant evidence was collected on MK-801 alleviating the effect of CLTIHH. Histological evaluations revealed lung damage and fibrotic changes in the CLTIHH groups. It was first shown that the CLTIHH procedure caused chronic lung injury, and that inflammation and oxidant stress were influential in the formation of lung injury. Secondly, NMDAR antagonist MK-801 effectively inhibited the development of lung injury and fibrosis.
dc.description.sponsorshipIstanbul University-Cerrahpas, a Scientific Research Projects Coordination Unit [25914]
dc.description.sponsorshipThis study was funded by the Istanbul University-Cerrahpas, a Scientific Research Projects Coordination Unit (25914).
dc.identifier.doi10.1590/1414-431X2023e12549
dc.identifier.issn0100-879X
dc.identifier.issn1414-431X
dc.identifier.pmid36995874
dc.identifier.scopus2-s2.0-85150762779
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1590/1414-431X2023e12549
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12175
dc.identifier.volume56
dc.identifier.wosWOS:000961867400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüner, İbrahim
dc.language.isoen
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChronic long-term intermittent hypoxia
dc.subjectLung injury
dc.subjectGlutamate
dc.subjectMK-801
dc.subjectNMDARs
dc.subjectObstructive Sleep-Apnea
dc.subjectPulmonary Inflammation
dc.subjectOxidative Stress
dc.subjectHypertension
dc.subjectFibrosis
dc.subjectMk-801
dc.titleThe role of NMDA glutamate receptors in lung injury caused by chronic long-term intermittent hypobaric hypoxia
dc.typeArticle

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