Protective effects of fish omega-3 fatty acids on doxorubicin-induced testicular apoptosis and oxidative damage in rats

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dc.authorscopusid26434076100
dc.authorscopusid24436194200
dc.authorscopusid8514414100
dc.authorscopusid55558318400
dc.authorscopusid7006356462
dc.authorscopusid36023238400
dc.authorscopusid25647609500
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidUYGUR, EMİNE/AAC-4470-2020
dc.contributor.authorUygur, Ramazan
dc.contributor.authorAktaş, Cevat
dc.contributor.authorTülübaş, Feti
dc.contributor.authorUygur, Emine
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorÖzen, Oğuz Aslan
dc.date.accessioned2022-05-11T14:07:36Z
dc.date.available2022-05-11T14:07:36Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Terapi ve Rehabilitasyon Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractThe aim of this study was to examine the protective effects of fish omega-3 (n-3) fatty acids on acute doxorubicin (DOX)-induced testicular apoptosis and oxidative damage. 24 male rats were divided into three groups: control, DOX-treated and DOX+fish n-3 fatty acids. Fish n-3 fatty acids (400 mg kg(-1)) were given for 30 days by intragastric gavage. The rats received a single intraperitoneal injection of DOX (30 mg kg(-1)) and were sacrificed after 48 h. The DOX+fish n-3 fatty acids group showed a decrease in malondialdehyde levels and increased activities of superoxide dismutase and glutathione peroxidase in comparison with the DOX-treated group. Acute DOX treatment caused severe damage such as disorganisation and separation of germ cells. The fish n-3 fatty acids-pretreated rats showed an improved histological appearance in the DOX-treated group. Our data indicate a reduction in the activity of terminal deoxynucleotidyl transferase mediated dUTP nick end labelling; there was a rise in the expression of proliferating cell nuclear antigen in testis tissues of the DOX+fish n-3 fatty acids group compared with DOX-treated group. These data suggested that fish n-3 fatty acids pre-treatment may be beneficial for spermatogenesis following acute DOX-induced testicular damage by decreasing germ cell apoptosis and oxidative stress.
dc.identifier.doi10.1111/and.12173
dc.identifier.endpage926
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue8en_US
dc.identifier.pmid24117968
dc.identifier.scopus2-s2.0-85007241787
dc.identifier.scopusqualityQ2
dc.identifier.startpage917
dc.identifier.urihttps://doi.org/10.1111/and.12173
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5155
dc.identifier.volume46
dc.identifier.wosWOS:000342811000014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUygur, Ramazan
dc.institutionauthorAktaş, Cevat
dc.institutionauthorTülübaş, Feti
dc.institutionauthorUygur, Emine
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorÖzen, Oğuz Aslan
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectdoxorubicin
dc.subjectfish omega-3 fatty acids
dc.subjectproliferating cell nuclear antigen
dc.subjecttestis
dc.subjectEssential Fatty-Acids
dc.subjectGerm-Cell Apoptosis
dc.subjectLipid-Peroxidation
dc.subjectPrefrontal Cortex
dc.subjectStress
dc.subjectToxicity
dc.subjectTestis
dc.subjectSpermatogenesis
dc.subjectMembranes
dc.subjectMice
dc.titleProtective effects of fish omega-3 fatty acids on doxorubicin-induced testicular apoptosis and oxidative damage in rats
dc.typeArticle

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