The effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats

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dc.authorid0000-0001-6236-0050
dc.authorscopusid16024976400
dc.authorscopusid7005410154
dc.authorscopusid56436052300
dc.authorscopusid56850131700
dc.authorscopusid57193085626
dc.authorwosidUysal, Ahmet Çağrı/AAJ-2949-2021
dc.contributor.authorOrhan, Erkan
dc.contributor.authorUysal, Ahmet Çağrı
dc.contributor.authorBaşer, Engin
dc.contributor.authorKeskin, Dürdane
dc.contributor.authorDemiroğlu Yakut, Çiğdem
dc.date.accessioned2022-05-11T14:36:52Z
dc.date.available2022-05-11T14:36:52Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.description.abstractPurpose: To evaluate the effect of inactive form of platelet rich plasma (PRP) on the flap viability. Methods: Thirty six rats were used. Rats were divided into six groups then 9x3 cm random pattern skin flaps were elevated from dorsum of all rats. For precluding vascularization from the base, a silicone layer was placed under the flap in groups 2(only flap+silicone), 4(saline+silicone) and 6(PRP+silicone). In groups 1(only flap), 2(only flap+silicone) nothing was done except flap surgery. In groups 3(saline) and 4(saline+silicone), saline was applied intradermally, in groups 5(PRP) and 6(PRP+silicone), inactive form of PRP which obtained from different 16 rats was applied intradermally, into certain points of flaps immediately after surgery. After 7 days flap necrosis ratio was measured in all groups. Results: Mean necrosis rate in group 5(PRP) (16.05%) was statistically significantly lower than group 1(only flap) (31,93%) and group 3(saline) (30,43%) (p < 0.001). Mean necrosis rate in group 6(PRP+silicone) (36.37%) was statistically significantly lower than group 2(only flap+silicone) (47.93%) and group 4(saline+silicone) (45.65%) (p < 0.001). Conclusion: Intradermal inactive platelet rich plasma administration decreases flap necrosis so for skin application.
dc.identifier.doi10.1590/s0102-865020170040000003
dc.identifier.endpage286
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue4en_US
dc.identifier.pmid28538802
dc.identifier.scopus2-s2.0-85019904786
dc.identifier.scopusqualityQ3
dc.identifier.startpage280
dc.identifier.urihttps://doi.org/10.1590/s0102-865020170040000003
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8449
dc.identifier.volume32
dc.identifier.wosWOS:000401985300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOrhan, Erkan
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPlatelet-Rich Plasma
dc.subjectSurgical Flaps
dc.subjectSkin
dc.subjectRats
dc.subjectGene-Expression
dc.subjectSurvival Rates
dc.subjectCells
dc.subjectPrp
dc.titleThe effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats
dc.typeArticle

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