Associations between genetic variants of the POU1F1 gene and production traits in Saanen goats

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dc.authorid0000-0003-2982-6562
dc.authorid0000-0003-2982-6562
dc.authorwosidISIK, RAZIYE/O-2454-2019
dc.authorwosidIşık, Raziye/V-4030-2017
dc.contributor.authorIşık, Raziye
dc.contributor.authorBilgen, Güldehen
dc.date.accessioned2022-05-11T14:02:56Z
dc.date.available2022-05-11T14:02:56Z
dc.date.issued2019
dc.departmentFakülteler, Ziraat Fakültesi, Tarımsal Biyoteknoloji Bölümü
dc.departmentFakülteler, Ziraat Fakültesi, Zootekni Bölümü
dc.description.abstractThis study was conducted to determine the polymorphisms of the POU1F1 gene and their relationships with milk yield and components, litter size, birth weight, and weaning weight in goats. For this purpose, a total of 108 Saanen goats from two different farms (Bornova and Manisa) were used as animal materials. Polymorphisms at the exon 6 and the 3' flanking region of the POU1F1 gene were determined by using PCR-RFLP with PstI and AluI restriction enzymes and DNA sequencing analyses. Two alleles and three genotypes were identified by AluI or PstI digestions of the POU1F1 gene. The genotypes frequencies of TT, TC, and CC were 64.8 %, 31.5 % and 3.7 % for the PstI locus; 54.6 %, 31.5 % and 13.9 % for the AluI locus, respectively. T allele frequencies (0.56 and 0.88 for the AluI locus, 0.80 and 0.81 for the PstI locus, respectively) were predominant in both loci at the Bornova and Manisa farms. In terms of POU1F1-AluI and POU1F1-PstI loci, two populations were found to be in Hardy-Weinberg equilibrium. In the POU1F1-Alullocus, significant associations were found between genotypes and lactation milk yield and litter size. Similarly, a significant relationship between genotypes and birth weight in the POU1F1-PstI locus (p < 0.05) was determined. The TC and CC genotypes were observed to be higher than the TT genotype for lactation milk yield and litter size at the POU1F1-AluI locus. Birth weight was found to be higher in animals that have the CC genotype at the POU1F1-PstI locus. In conclusion, the POU1F1 gene can be used as a molecular marker for economic features like reproduction, growth, milk content and yield in Saanen goats.
dc.description.sponsorshipPriority Areas National Scholarship Program [TUBITAK-BIDEB 2211-C]
dc.description.sponsorshipThis paper is a summary of the PhD thesis of the first author, who was supported by TUBITAK-BIDEB 2211-C Priority Areas National Scholarship Program for PhD Students.
dc.identifier.doi10.5194/aab-62-249-2019
dc.identifier.endpage255
dc.identifier.issn0003-9438
dc.identifier.issn2363-9822
dc.identifier.issue1en_US
dc.identifier.pmid31807635
dc.identifier.startpage249
dc.identifier.urihttps://doi.org/10.5194/aab-62-249-2019
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4546
dc.identifier.volume62
dc.identifier.wosWOS:000466883100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorIşık, Raziye
dc.institutionauthorBilgen, Güldehen
dc.language.isoen
dc.publisherCopernicus Gesellschaft Mbh
dc.relation.ispartofArchives Animal Breeding
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPcr-Rflp
dc.subjectBlood Metabolites
dc.subjectGrowth-Hormone
dc.subjectLitter Size
dc.subjectPolymorphism
dc.subjectBovine
dc.subjectLocus
dc.subjectPit-1
dc.subjectSnps
dc.titleAssociations between genetic variants of the POU1F1 gene and production traits in Saanen goats
dc.typeArticle

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