Morphological investigation of alcohol-induced hepatocyte apoptosis and liver injury in rats

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dc.authorscopusid24436194200
dc.authorscopusid7006356462
dc.authorscopusid55134339900
dc.authorscopusid57193693689
dc.contributor.authorAktaş, Cevat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorDönmez, Yeliz Bozdemir
dc.contributor.authorÖztürk, Şamil
dc.date.accessioned2022-05-11T14:41:25Z
dc.date.available2022-05-11T14:41:25Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to morphologicall investigation of alcohol-induced hepatocyte apoptosis and liver injury in rats. A total of 20 male Sprague-Dawley rats were divided into two groups: control, and alcohol treated; each group contain 10 animals. The rats in alcohol treated group was given a daily dose of 6 g/kg ethanol by using intragastric intubation. Control group was given the same volume of saline. This application was continued daily for a total of 6 weeks. The end of the experiment all animals were anesthetized. The anesthetized rats were sacrificed and liver tissues were removed for histopathological investigation. Liver damage was examined by using hematoxylin-eosin and apoptosis was determined by terminal-deoxynucleotidyl- transferase mediated dUTP nick end labeling (TUNEL). There existed hepatocyte diffuse steatosis and hemorrhage in alcohol treated group. Our data indicate an enhancement in the activity of TUNEL in hepatocyte apoptosis of the alcholol treated group. The effects of alcohol on liver can be clearly detected as a hepatocyte cell death and liver injury. © 2011 OMU All rights reserved.
dc.identifier.doi10.5835/jecm.omu.28.03.003
dc.identifier.endpage106
dc.identifier.issn1300-2996
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84858812538
dc.identifier.scopusqualityN/A
dc.identifier.startpage103
dc.identifier.urihttps://doi.org/10.5835/jecm.omu.28.03.003
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9175
dc.identifier.volume28
dc.indekslendigikaynakScopus
dc.institutionauthorAktaş, Cevat
dc.institutionauthorDönmez, Yeliz Bozdemir
dc.language.isoen
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlcohol
dc.subjectHepatocyte apoptosis
dc.subjectLiver injury
dc.subjectRat
dc.subjectSteatosis
dc.subjectTUNEL
dc.titleMorphological investigation of alcohol-induced hepatocyte apoptosis and liver injury in rats
dc.typeArticle

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