Altered methyltetrahydrofolate reductase gene polymorphism in mothers of children with attention deficit and hyperactivity disorder

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dc.authorid0000-0002-0393-3135
dc.authorid0000-0002-5770-344X
dc.authorscopusid25633859900
dc.authorscopusid15764510600
dc.authorscopusid54791156900
dc.authorscopusid29067508300
dc.authorscopusid57203164035
dc.authorscopusid36523620300
dc.authorscopusid55315126400
dc.authorwosidKarabekiroglu, Koray/G-4424-2011
dc.authorwosidBEYAZYUZ, MURAT/ABA-7934-2020
dc.authorwosidPotas, Nihan/F-6876-2016
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.contributor.authorBaykal, Saliha
dc.contributor.authorBatar, Bahadır
dc.contributor.authorNalbantoğlu, Ayşin
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorHanci, Halil
dc.contributor.authorPotas, Nihan
dc.contributor.authorKarabekiroğlu, Koray
dc.date.accessioned2022-05-11T14:10:02Z
dc.date.available2022-05-11T14:10:02Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractAttention Deficit and Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in childhood and causes significant functional impairments in children. Behavioral genetic and molecular genetic studies have provided significant evidence in terms of highlighting the etiology of ADHD. Folate deficiency during pregnancy is an established risk factor for ADHD. Polymorphisms in the Methyltetrahydrofolate Reductase (MTHFR) encoding gene, such as A1298C and C667T, are associated with the decreased bioavailability of folate, and this condition can act like folate deficiency. In the literature, no study has investigated MTHFR polymorphisms in mothers of children with ADHD. Sixty-four children diagnosed with ADHD and their mothers as well as 40 healthy children and their mothers participated in this study. MTHFR polymorphisms were investigated in all participants. Comparison of the C677C and A1298C MTHFR polymorphisms in children with and without ADHD revealed no significant differences. We found that the maternal C677C_CT genotype counts, both observed and expected values, were significantly different from those based on Hardy-Weinberg Principle Analysis in the ADHD group. The most important result of this study was that maternal C677C MTHFR gene polymorphisms are significant risk factors in for ADHD, and we argue that children with ADHD are exposed to folate deficiency, even if their mothers received a sufficient amount of folate during pregnancy. This result also highlights one of the genetic factors of ADHD. Further studies should be performed to confirm this finding.
dc.description.sponsorshipTekirdag Namik Kemal University Scientific Research Community [NKUBAP.02.GA.16.067]
dc.description.sponsorshipPresent study was supported by Tekirdag Namik Kemal University Scientific Research Community (NKUBAP.02.GA.16.067).
dc.identifier.doi10.1016/j.pnpbp.2018.07.020
dc.identifier.endpage221
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.pmid30053573
dc.identifier.scopus2-s2.0-85050730745
dc.identifier.scopusqualityQ1
dc.identifier.startpage215
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2018.07.020
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5259
dc.identifier.volume88
dc.identifier.wosWOS:000445634300023
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBaykal, Saliha
dc.institutionauthorBatar, Bahadır
dc.institutionauthorNalbantoğlu, Ayşin
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorHanci, Halil
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAttention
dc.subjectHyperactivity
dc.subjectMother
dc.subjectMethyltetrahydrofolate reductase
dc.subjectGene
dc.subjectPolymorphism
dc.subjectNeural-Tube Defects
dc.subjectMethylenetetrahydrofolate-Reductase
dc.subjectFolic-Acid
dc.subjectDeficit/Hyperactivity Disorder
dc.subjectMolecular-Genetics
dc.subjectFolate
dc.subjectDisease
dc.subjectAdhd
dc.subjectMetaanalysis
dc.subjectPregnancy
dc.titleAltered methyltetrahydrofolate reductase gene polymorphism in mothers of children with attention deficit and hyperactivity disorder
dc.typeArticle

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