MIRNA-mediated regulation of the PI3K/AKT signaling pathway in colorectal cancer: A study based on data mining

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dc.contributor.authorBozgeyik, Esra
dc.contributor.authorBozgeyik, İbrahim
dc.date.accessioned2022-05-11T14:42:06Z
dc.date.available2022-05-11T14:42:06Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractAim: In colorectal cancer (CRC), expression of genes involved in the PI3K/Akt signaling pathway varies significantly. Studies haveshown that microRNAs (miRNA) have important roles in the development of CRC. Accordingly, the aim of this study was to determinemiRNAs affecting the critical genes in the PI3K/Akt pathway by analysis of The Cancer Genome Atlas (TCGA) CRC data sets and toevaluate the clinical significance of these miRNAs.Material and Methods: Initially, CRC mRNA, miRNA expression levels and patient data were obtained from TCGA database. The studyincluded 220 CRC patients. MiRNAs that were negatively correlated with genes in the PI3K/Akt signaling pathway were selected, andtheir expression levels were compared with the clinical and demographic characteristics of CRC patients.Results: miR-18a, miR-19b, miR-17, miR-106b, miR-130b and miR-135b were found to be negatively correlated with genes that playkey roles in the PI3K/Akt pathway. Also, miR-18a, miR-19b, miR-17 and miR-135b were found to vary significantly according to theCRC subtype.Conclusion: Consequently, the PI3K/Akt signaling pathway was found to be deregulated in CRC and the majority of genes involved inthis signaling pathway were associated with miRNAs. Thus, PI3K/Akt miRNA axis might serve as a potentially distinctive diagnostic,prognostic and therapeutic avenue against CRC.
dc.identifier.doi10.5455/annalsmedres.2019.10.617
dc.identifier.endpage2835
dc.identifier.issn2636-7688
dc.identifier.issn2636-7688
dc.identifier.issue12en_US
dc.identifier.startpage2827
dc.identifier.trdizinidTXpVNU1UQXpNdz09
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2019.10.617
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpVNU1UQXpNdz09
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9227
dc.identifier.volume26
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBozgeyik, Esra
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMIRNA-mediated regulation of the PI3K/AKT signaling pathway in colorectal cancer: A study based on data mining
dc.typeArticle

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