Molecular etiology of arthrogryposis in multiple families of mostly Turkish origin

Basit Öğe Kaydı
dc.authorid0000-0001-8308-1309
dc.authorid0000-0003-3425-2727
dc.authorid0000-0002-2432-9279
dc.authorid0000-0002-2432-9279
dc.authorid0000-0003-0103-9612
dc.authorid0000-0001-6415-8323
dc.authorid0000-0002-0941-4571
dc.authorscopusid56262251700
dc.authorscopusid16203264000
dc.authorscopusid56503630300
dc.authorscopusid56251785900
dc.authorscopusid26533426400
dc.authorscopusid36240446700
dc.authorscopusid26645221500
dc.authorwosidBAYHAN, ILHAN/L-5947-2018
dc.authorwosidAYDIN, Hatip/A-2711-2017
dc.authorwosidKaraman, Ali/V-5164-2019
dc.authorwosidPehlivan, Davut/I-3235-2019
dc.authorwosidGezdirici, Alper/W-8459-2018
dc.authorwosidGezdirici, Alper/AAG-5480-2019
dc.authorwosidaydin, hatip/AAE-5540-2021
dc.contributor.authorBayram, Yavuz
dc.contributor.authorKaraca, Ender
dc.contributor.authorAkdemir, Zeynep Çoban
dc.contributor.authorYılmaz, Elif Ozdamar
dc.contributor.authorTayfun, Gülsen Akay
dc.contributor.authorAydın, Hatip
dc.contributor.authorLupski, James R.
dc.date.accessioned2022-05-11T14:42:07Z
dc.date.available2022-05-11T14:42:07Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractBACKGROUND. Arthrogryposis, defined as congenital, joint contractures in 2 or more body areas, is a clinical sign rather than a specific disease diagnosis. To date, more than 400 different disorders have been described that present with arthrogryposis, and variants of more than 220 genes have been associated with these disorders; however, the underlying molecular etiology remains unknown in the considerable majority of these cases. METHODS. We performed whole exome sequencing (WES) of 52 patients with clinical presentation of arthrogryposis from 48 different families. RESULTS. Affected individuals from 17 families (35.4%) had variants in known arthrogryposis-associated genes, including homozygous variants of cholinergic gamma nicotinic receptor (CHRNG, 6 subjects) and endothelin converting enzyme-like 1 (ECELI, 4 subjects). Deleterious variants in candidate arthrogryposis-causing genes (fibrillin 3 [FBN3], myosin IXA [MY09A], and pleckstrin and Sec7 domain containing 3 [PSD3]) were identified in 3 families (6.2%). Moreover, in 8 families with a homozygous mutation in an arthrogryposis-associated gene, we identified a second locus with either a homozygous or compound heterozygous variant in a candidate gene (myosin binding protein C, fast type (MYBPC2] and vacuolar protein sorting 8 [VPS8], 2 families, 4.2%) or in another disease-associated genes (6 families, 12.5%), indicating a potential mutational burden contributing to disease expression. CONCLUSION. In 58.3% of families, the arthrogryposis manifestation could be explained by a molecular diagnosis; however, the molecular etiology in subjects from 20 families remained unsolved by WES. Only 5 of these 20 unrelated subjects had a clinical presentation consistent with amyoplasia; a phenotype not thought to be of genetic origin. Our results indicate that increased use of genome-wide technologies will provide opportunities to better understand genetic models for diseases and molecular mechanisms of genetically heterogeneous disorders, such as arthrogryposis. FUNDING. This work was supported in part by US National Human Genome Research Institute (NHGRI)/National Heart, Lung, and Blood Institute (NHLBI) grant U54HG006542 to the Baylor-Hopkins Center for Mendelian Genomics, and US National Institute of Neurological Disorders and Stroke (NINDS) grant RO1NS058529 to J.R. Lupski.
dc.description.sponsorshipUS NHGRI/NHLBI [U54HG006542]; US NINDSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS058529]; CPRIT training Program [RP140102]; Medical Genetics Research Fellowship Program [T32 GM07526]; NATIONAL HUMAN GENOME RESEARCH INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Human Genome Research Institute (NHGRI) [U54HG006542] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [T32GM007526] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS058529] Funding Source: NIH RePORTER
dc.description.sponsorshipWe thank the patients and their families who participated in this study. This work was supported in part by US NHGRI/NHLBI grant U54HG006542 to the Baylor-Hopkins Center for Mendelian Genomics and US NINDS grant R01NS058529 to J.R. Lupski. W.L. Charng is supported by CPRIT training Program RP140102, and T. Harel is supported by the T32 GM07526 Medical Genetics Research Fellowship Program.
dc.identifier.doi10.1172/JCI84457
dc.identifier.endpage778
dc.identifier.issn0021-9738
dc.identifier.issn1558-8238
dc.identifier.issue2en_US
dc.identifier.pmid26752647
dc.identifier.scopus2-s2.0-84956873601
dc.identifier.scopusqualityQ1
dc.identifier.startpage762
dc.identifier.urihttps://doi.org/10.1172/JCI84457
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9233
dc.identifier.volume126
dc.identifier.wosWOS:000370677300034
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Hatip
dc.language.isoen
dc.publisherAmer Soc Clinical Investigation Inc
dc.relation.ispartofJournal of Clinical Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDistal Arthrogryposis
dc.subjectCongenital Contractures
dc.subjectPterygium Syndrome
dc.subjectFetal Akinesia
dc.subjectDiagnostic-Approach
dc.subjectRenal Dysfunction
dc.subjectMutations
dc.subjectClassification
dc.subjectPhenotype
dc.subjectMyopathy
dc.titleMolecular etiology of arthrogryposis in multiple families of mostly Turkish origin
dc.typeArticle

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