Carotid intima-media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study

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dc.authorid0000-0002-3535-5704
dc.authorid0000-0002-9435-8307
dc.authorid0000-0001-6160-3778
dc.authorid0000-0002-3731-2978
dc.authorid0000-0001-8388-9500
dc.authorid0000-0001-6320-0470
dc.authorid0000-0002-8328-295X
dc.authorscopusid8531050100
dc.authorscopusid21735417700
dc.authorscopusid15073024800
dc.authorscopusid56002962900
dc.authorscopusid56780380500
dc.authorscopusid56208656300
dc.authorscopusid6508341165
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.authorwosidGulbas, Gazi/ABI-5182-2020
dc.authorwosidOgan, Nalan/ABB-8400-2020
dc.authorwosidDuyar, Sezgi Sahin/AAU-4149-2021
dc.authorwosidDemirci, Nilgün Yılmaz/C-9348-2014
dc.authorwosidbeyan, ayse coskun/Q-8940-2017
dc.authorwosidDiken, Özlem Erçen/AAI-6625-2021
dc.contributor.authorGulbas, Gazi
dc.contributor.authorTuran, Onur
dc.contributor.authorSarıoğlu, Nurhan
dc.contributor.authorDiken, Özlem Ercen
dc.contributor.authorOgan, Nalan
dc.contributor.authorKadioglu, Esra Ekbic
dc.contributor.authorSuerdem, Mecit
dc.contributor.authorMutlu, Levent Cem
dc.date.accessioned2022-05-11T14:39:48Z
dc.date.available2022-05-11T14:39:48Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Carotid intima-media thickness (CIMT) is a noninvasive method assessing atherosclerosis. Objective It was aimed to determine relationship and survival between COPD and CIMT. Methods CIMT was measured using Doppler ultrasound (USG) in 668 stable COPD patients at 24 centers. Patients were followed-up for 2 years. Results There were 610 patients who completed the study. There were 200 patients CIMT with <0.78 mm (group 1), and 410 with CIMT >= 0.78 mm (group 2). There was a significant difference at the parameters of age, gender, smoking load, biomass exposure, GOLD groups and degree of airway obstruction (FEV1) between groups 1 and 2. Our results revealed positive correlations between mean CIMT and age, smoking load (pack-years), biomass exposure (years), exacerbation rate (last year), duration of hypertension (years) and cholesterol level; negative correlations between CIMT and FEV1 (P < 0.05). According to logistic regression model, compared with group A, risk of CIMT increase was 2.2-fold in group B, 9.7-fold in group C and 4.4-fold in group D (P < 0.05). Risk of CIMT increase was also related with cholesterol level (P < 0.05). Compared with infrequent exacerbation, it was 2.8-fold in the patients with frequent exacerbation (P < 0.05). The mean survival time was slightly higher in group 1, but not significant (23.9 vs 21.8 months) (P > 0.05). Conclusion This study is the first regarding CIMT with combined GOLD assessment groups. It has revealed important findings supporting the increase in atherosclerosis risk in COPD patients. We recommend Doppler USG of the carotid artery in COPD patients at severe stages.
dc.identifier.doi10.1111/crj.13024
dc.identifier.endpage399
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue6en_US
dc.identifier.pmid30942958
dc.identifier.scopus2-s2.0-85066013688
dc.identifier.scopusqualityQ3
dc.identifier.startpage391
dc.identifier.urihttps://doi.org/10.1111/crj.13024
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8731
dc.identifier.volume13
dc.identifier.wosWOS:000470921200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMutlu, Levent Cem
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcarotid intima-media
dc.subjectCOPD
dc.subjectexacerbation
dc.subjectsurvival
dc.subjectCardiovascular-Disease
dc.subjectCopd
dc.subjectRisk
dc.subjectAtherosclerosis
dc.subjectInflammation
dc.subjectMortality
dc.subjectSecondary
dc.titleCarotid intima-media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study
dc.typeArticle

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