Poor Biological Factors and Prognosis of Interval Breast Cancers: Long-Term Results of Bahceehir (Istanbul) Breast Cancer Screening Project in Turkey

Basit Öğe Kaydı
dc.authorid0000-0002-5525-8696
dc.authorscopusid56037273500
dc.authorscopusid8204207500
dc.authorscopusid25027835200
dc.authorscopusid22234916200
dc.authorscopusid55916941500
dc.authorscopusid57218194642
dc.authorscopusid16687052800
dc.authorwosidGurdal, Sibel Ozkan/ABA-3882-2020
dc.authorwosidCabıoğlu, Neslihan/AAZ-1196-2020
dc.authorwosidAribal, Erkin/X-6448-2018
dc.authorwosidOzmen, Vahit/AAE-3904-2020
dc.contributor.authorCabıoğlu, Neslihan
dc.contributor.authorGürdal, Sibel Özkan
dc.contributor.authorKayhan, Arda
dc.contributor.authorÖzaydın, Niluefer
dc.contributor.authorŞahin, Cennet
dc.contributor.authorCan, OEmuer
dc.contributor.authorÖzmen, Vahit
dc.date.accessioned2022-05-11T14:34:59Z
dc.date.available2022-05-11T14:34:59Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractPURPOSE The Turkish Bahceehir Breast Cancer Screening Project was a 10-year, organized, population-based screening program carried out in Bahceehir county, Istanbul. Our aim was to examine the biologic features and outcome of screen-detected and interval breast cancers during the 10-year study period. METHODS Between 2009 and 2019, 2-view mammograms were obtained at 2-year intervals for women aged 40 to 69 years. Clinicopathological characteristics including ER, PR, HER2-neu, and Ki-67 status were analyzed for those diagnosed with breast cancer. RESULTS In 8,758 screened women, 131 breast cancers (1.5%) were detected. The majority of patients (82.3%) had prognostic stage 0-I disease. Contrarily, patients with interval cancers (n = 15; 11.4%) were more likely to have a worse prognostic stage (II-IV disease; odds ratio [OR], 3.59, 95% CI, 0.9 to 14.5) and high Ki-67 scores (OR, 3.14; 95% CI, 0.9 to 11.2). Interval cancers detected within 1 year were more likely to have a luminal B (57.1% v 31.9%) and triple-negative (14.3% v 1%) subtype and less likely to have a luminal A subtype (28.6% v 61.5%; P = .04). Patients with interval cancers had a poor outcome in 10-year disease-specific (DSS) and disease-free survival (DFS) compared with those with screen-detected cancers (DSS: 68.2% v 98.1%, P = .002; DFS: 78.6% v 96.5%, P = .011). CONCLUSION Our findings suggest the majority of screen-detected breast cancers exhibited a luminal A subtype profile with an excellent prognosis. However, interval cancers were more likely to have aggressive subtypes such as luminal B subtype or triple-negative cancers associated with a poor prognosis requiring other preventive strategies. (c) 2020 by American Society of Clinical Oncology
dc.description.sponsorshipRocheRoche Holding; Basaksehir (Basaksehir county in Istanbul) Municipality
dc.description.sponsorshipSupported by a grant from Roche (V.O.) and Basaksehir (Bahcesehir is a region in the Basaksehir county in Istanbul) Municipality.
dc.identifier.doi10.1200/GO.20.00145
dc.identifier.endpage1113
dc.identifier.issn2687-8941
dc.identifier.pmid32678710
dc.identifier.scopus2-s2.0-85088221747
dc.identifier.scopusqualityQ1
dc.identifier.startpage1103
dc.identifier.urihttps://doi.org/10.1200/GO.20.00145
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8164
dc.identifier.volume6
dc.identifier.wosWOS:000564861600023
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGürdal, Sibel Özkan
dc.language.isoen
dc.publisherAmer Soc Clinical Oncology
dc.relation.ispartofJco Global Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMammography
dc.subjectProgram
dc.subjectBiomarkers
dc.subjectImpact
dc.subjectRisk
dc.subjectCarcinomas
dc.subjectExpression
dc.subjectMortality
dc.subjectStage
dc.subjectAge
dc.titlePoor Biological Factors and Prognosis of Interval Breast Cancers: Long-Term Results of Bahceehir (Istanbul) Breast Cancer Screening Project in Turkey
dc.typeArticle

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