The Role of Adipocytokines in Colon Cancer and Adenomas

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dc.authorid0000-0002-6396-3168
dc.contributor.authorTülübaş, Feti
dc.contributor.authorMete, Rafet
dc.contributor.authorÖznur, Meltem
dc.contributor.authorTopçu, Birol
dc.date.accessioned2022-05-11T14:07:44Z
dc.date.available2022-05-11T14:07:44Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractBackground: Metabolic changes resulting from obesity, insulin insensitivity, and imbalances in hormones such as adiponectin, leptin, resistin, apelin and visfatin, which are derived from white adipose tissue-derived hormone, are directly linked to both colon cancer (CC) and inflammatory bowel diseases increasing tissue-derived risk. We conducted this study to evaluate the relationship between the circulating concentrations of adiponectin, leptin, resistin, apelin and visfatin and colon adenoma and CC. Methods: Our study included 90 participants aged >18 years who were divided into three groups: colon cancer, adenoma and control. The serum concentrations of the investigated adipohormones were measured with ELISA in 30 patients with colon adenoma, 30 with CC and 30 controls with no colon pathology. Results: Demographic, anthropometric, metabolic and hormonal parameters were also recorded. The group means were compared by using one-way analysis of variance (ANOVA). Dual comparisons between groups were analyzed with the Tukey test. Pearson correlation coefficient was used to determine the relation between continuous variables. Adiponectin and leptin levels in patients with adenomas (p<0.000; p<0.000, respectively) and CC (p<0.000; p<0.000, respectively) were lower than in controls. Apelin level in patients with CC (p<0.000; p<0.000, respectively) was lower than in patients with adenomas and in controls. Resistin and visfatin levels in patients with CC (p<0.000; p<0.000, respectively) were higher than in patients with adenomas and in controls. Conclusions: We have concluded that adiponectin, leptin, resistin, apelin and visfatin levels may play an important role in colon carcinogenesis. We also assume that adiponectin and leptin may be associated with the risk of colon adenoma.
dc.identifier.doi10.2478/jomb-2013-0001
dc.identifier.endpage142
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84904330877
dc.identifier.scopusqualityQ3
dc.identifier.startpage135
dc.identifier.urihttps://doi.org/10.2478/jomb-2013-0001
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5187
dc.identifier.volume33
dc.identifier.wosWOS:000332683700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTülübaş, Feti
dc.institutionauthorMete, Rafet
dc.institutionauthorÖznur, Meltem
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherSoc Medical Biochemists Serbia
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectadiponectin
dc.subjectapelin
dc.subjectvisfatin
dc.subjectcolon adenoma
dc.subjectcolon cancer
dc.subjectColorectal Carcinogenesis
dc.subjectAdiponectin
dc.subjectLeptin
dc.subjectResistin
dc.subjectBreast
dc.subjectExpression
dc.subjectVisfatin
dc.subjectApelin
dc.subjectRisk
dc.subjectProliferation
dc.titleThe Role of Adipocytokines in Colon Cancer and Adenomas
dc.typeArticle

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