Effects of Chronic Oral Monosodium Glutamate Consumption on Naloxane-Induced Morphine Withdrawal in Infant Rats

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dc.contributor.authorYananlı, Hasan Raci
dc.contributor.authorYıldız, Merve
dc.contributor.authorTemel, Hasan
dc.contributor.authorKılınç, Melih
dc.contributor.authorÖzen, Berna
dc.contributor.authorDemirkapu, Mahluga Jafarova
dc.contributor.authorKutluay, Sena Nur
dc.date.accessioned2023-05-06T17:23:35Z
dc.date.available2023-05-06T17:23:35Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractAim: The aim of this study was to investigate chronic oral monosodium glutamate (MSG) consumption effects on symptoms of withdrawal, locomotor activity, and anxiety in morphine withdrawal syndrome induced by naloxone in infant rats. Materials and Methods: Twelve 21-day-old male Wistar rats used in the study. Infant rats were given unlimited access to saline (control group) or MSG (MSG group) added to drinking water for 32 days. Withdrawal was induced by naloxone in morphine-dependent rats. Evaluation of withdrawal symptoms and anxiety were performed simultaneously with locomotor activity measurements. Results: Withdrawal sings, such as jumping, wet dog shake, and weight loss; stereotypic, ambulatory, and vertical locomotor activity movements; central, peripheral, and total activities used in the assessment of anxiety in infant rats with naloxone-induced withdrawal syndrome that consumed oral MSG for 32 days were not different from the control group. Conclusion: These findings obtained in our study indicate that chronic consumption of oral MSG in infant rats whose blood-brain barrier has not yet developed does not affect morphine dependence and naloxone-induced withdrawal. Further studies are needed to investigate the mechanism of action of orally administered MSG.
dc.identifier.doi10.29058/mjwbs.1124034
dc.identifier.endpage384
dc.identifier.issn2822-4302
dc.identifier.issn2587-0602
dc.identifier.issue3en_US
dc.identifier.startpage378
dc.identifier.trdizinid1154093
dc.identifier.urihttps://doi.org/10.29058/mjwbs.1124034
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1154093
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12173
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorDemirkapu, Mahluga Jafarova
dc.language.isoen
dc.relation.ispartofBatı Karadeniz Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectanxiety
dc.subjectjumping
dc.subjectlocomotor activity
dc.subjectweight loss
dc.subjectwet dog shake Kaygı
dc.subjectZıplama
dc.subjectLokomotor aktivite
dc.subjectKilo kaybı
dc.subjectIslak köpek silkinmesi
dc.titleEffects of Chronic Oral Monosodium Glutamate Consumption on Naloxane-Induced Morphine Withdrawal in Infant Rats
dc.typeArticle

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