Could Age and Oral Challenge Outcomes Identify High-Risk Patients During Cow's Milk Oral Immunotherapy?

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dc.authorscopusid57381733400
dc.authorscopusid57191168328
dc.authorscopusid57219209857
dc.authorscopusid57756767400
dc.authorscopusid37092966400
dc.authorscopusid9036191300
dc.authorscopusid7004473191
dc.contributor.authorŞenol, Handan Duman
dc.contributor.authorTopyıldız, Ezgi
dc.contributor.authorSevercan, Ezgi Ulusoy
dc.contributor.authorAkercan, Sanem Eren
dc.contributor.authorGünaydın, Nursen Ciğerci
dc.contributor.authorGülen, Figen
dc.contributor.authorDemir, Esen
dc.date.accessioned2023-04-20T08:01:16Z
dc.date.available2023-04-20T08:01:16Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Severe immunglobuline E (IgE)-mediated reactions during oral immunotherapy (OIT) are major obstacles to treatment. The present study aimed to evaluate and identify clinical and laboratory biomarkers of adverse events during OIT among children with cow's milk (CM) allergy.Study Design: Eighty-six children older than 36 months who had undergone OIT with milk were enrolled. Clinical data, oral food challenge (OFC) test results, and laboratory data were recorded retrospectively.Results: The median duration of the build-up phase of OIT was 19 weeks (min 10-max 40) and the duration of the maintenance phase was 86.5 (min 1-max 132) months. A total of 11,767 CM doses were administered during the build-up phase and adverse reactions were seen in 62 (73.8%) patients with reactions registered for 157 doses among 11,767 (1/75 doses). The number of reactions during the maintenance phase was 41 (47.6%) in 24 (27.9%) patients. There was a significant reduction in the number of reactions (P = 0.000) between the build-up phase and maintenance phase. Adverse reactions and anaphylaxis were higher for patients who had cough during OFC (P = 0.003, P = 0.002, respectively) during the build-up phase and also during the maintenance phase too (P = 0.000). Evaluation for all reactions and anaphylaxis (during build-up and maintenance) with Kaplan-Meier and Cox regression analysis showed class IV-VI of CM-specific immunoglobulin E (sIgE), casein-sIgE and cough during OFC were significantly associated with increased probability of reaction and anaphylaxis. Younger age at onset of OIT was associated with risk reduction (0.017).Conclusion: Laboratory data and reactions during the OFC (especially cough) can help to identify high-risk patients during OIT.
dc.identifier.doi10.1089/ped.2022.0003
dc.identifier.endpage101
dc.identifier.issn2151-321X
dc.identifier.issn2151-3228
dc.identifier.issue2en_US
dc.identifier.pmid35675663
dc.identifier.scopus2-s2.0-85132454343
dc.identifier.scopusqualityQ3
dc.identifier.startpage95
dc.identifier.urihttps://doi.org/10.1089/ped.2022.0003
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10841
dc.identifier.volume35
dc.identifier.wosWOS:000807882500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGünaydın, Nursen Ciğerci
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofPediatric Allergy Immunology and Pulmonology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdverse Reaction
dc.subjectAnaphylaxis
dc.subjectCow's Milk Allergy
dc.subjectChildren
dc.subjectOral Immunotherapy
dc.subjectAdverse Events
dc.subjectChildren
dc.subjectIge
dc.subjectPredictors
dc.subjectSafety
dc.subjectAllergy
dc.titleCould Age and Oral Challenge Outcomes Identify High-Risk Patients During Cow's Milk Oral Immunotherapy?
dc.typeArticle

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