The Prevalence of Mixed Genotype Infections in Turkish Patients with Hepatitis C: a Multicentered Assessment

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dc.authorid0000-0002-7762-4108
dc.authorid0000-0002-6455-5932
dc.authorid0000-0003-4393-5618
dc.authorid0000-0003-0411-9669
dc.authorid0000-0003-1115-0429
dc.authorid0000-0001-6750-2353
dc.authorid0000-0001-7672-3625
dc.authorscopusid6507113749
dc.authorscopusid57208658905
dc.authorscopusid26038972000
dc.authorscopusid55895076200
dc.authorscopusid57093607600
dc.authorscopusid6508232943
dc.authorscopusid7003941673
dc.authorwosidAYDIN, FARUK/AAL-6973-2021
dc.authorwosidAKTAS, OSMAN/Z-1102-2019
dc.authorwosidçekin, yeşim/AAL-9661-2020
dc.authorwosidgüreser, Ayşe semra/E-9513-2018
dc.authorwosidEce, Gulfem/AAN-7463-2020
dc.authorwosidKarslıgil, Tekin/AAD-6385-2022
dc.authorwosidAktas, Osman/K-9701-2019
dc.contributor.authorKulah, Canan
dc.contributor.authorAltindis, Mustafa
dc.contributor.authorAkyar, Işın
dc.contributor.authorGokahmetoglu, Selma
dc.contributor.authorSayiner, Arzu
dc.contributor.authorKaleli, Ilknur
dc.contributor.authorCömert , Fusun
dc.contributor.authorTopkaya, Aynur
dc.date.accessioned2022-05-11T14:42:11Z
dc.date.available2022-05-11T14:42:11Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractBackground: HCV virus infections are one of the major health problems in the world that can cause cirrhosis and liver cancer at a higher rate than other hepatitis data. The aim of this study was to determine the prevalence of mixed infections with different HCV genotypes in Turkey and also to evaluate the current HCV genot pe and subtype distributions by a multicentered assessment. Methods: The HCV genotype data of 17,578 hepatitis C patients collected from 23 centers from different geographic regions covering all Turkey were collected. The data included information about the HCV genotypes in the last 10 years (bail een 2007 and 2016), demographic properties of the patients and the methods/systems used to determine the genotypes. Results: Two hundred twenty-eight of the patients (1.3%) had mixed genotype. The most common mixed genotype combination was 1b + 4 (0.83%) followed by 1a + 1b (0.26%). Genotype distribution varies according to geographical regions. However, genotype 1 (82.92%) was the most common genotype in all regions and all years. This was followed by genotype 3 (7.07%) and genotype 4 (5.43%). A variety of methods were used by the centers including sequencing, pyrosequencing, real-time PCR, in-house RFLP, reverse hybridization (LIPA), and hybridization. Conclusions: Infection with mixed HCV genotypes in Turkey is uncommon. Genotype distribution varies according to geographic regions; the most common genotype 1 is encountered all oN er the country, while genotypes 3 and 4 are only in some of the centers. Since there is limited information about mixed HCV infection, further investigations are needed to determine the clinical importance of mixed HCV infection.
dc.identifier.doi10.7754/Clin.Lab.2018.180824
dc.identifier.endpage490
dc.identifier.issn1433-6510
dc.identifier.issue4en_US
dc.identifier.pmid30969089
dc.identifier.scopus2-s2.0-85064721774
dc.identifier.scopusqualityQ3
dc.identifier.startpage485
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2018.180824
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9267
dc.identifier.volume65
dc.identifier.wosWOS:000463988900008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTopkaya, Aynur
dc.language.isoen
dc.publisherClin Lab Publ
dc.relation.ispartofClinical Laboratory
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHCV
dc.subjectgenotypes
dc.subjectmixed genotypes
dc.subjectTurkey
dc.subjectmulticenter
dc.subjectVirus-Infection
dc.subjectTurkey
dc.titleThe Prevalence of Mixed Genotype Infections in Turkish Patients with Hepatitis C: a Multicentered Assessment
dc.typeArticle

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