Inverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern

Basit Öğe Kaydı
dc.authorid0000-0002-6396-3168
dc.authorscopusid15844109600
dc.authorscopusid56305145500
dc.authorscopusid26431693600
dc.authorscopusid14318868100
dc.authorscopusid8067129500
dc.contributor.authorÖznur, Meltem
dc.contributor.authorBaykal Koca, Sevim
dc.contributor.authorYıldız, Pelin
dc.contributor.authorBahadır, Burak
dc.contributor.authorBehzatoğlu, Kemal
dc.date.accessioned2022-05-11T14:36:55Z
dc.date.available2022-05-11T14:36:55Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractHigh-grade prostatic intraepithelial neoplasia (HGPIN) is considered to be an important precursor for prostatic adenocarcinoma. The present study aimed to investigate the histological features of the uncommon inverted (hobnail) pattern of HGPIN in transrectal ultrasonographic (TRUS) prostatic needle biopsies from 13 cases. These 13 diagnosed cases of inverted HGPIN were identified out of a total of 2,034 TRUS biopsies (0.63%), obtained from patients suspected to have prostate cancer. The hobnail pattern is comprised of secretory cell nuclei, which are histologically localized at the luminal surface of the prostate gland, rather than the periphery, and exhibit reverse polarity. Histological examinations were performed and the results demonstrated that 5 of the 13 cases exhibited pure inverted histology, while HGPIN was observed to be histologically associated with other patterns in the remaining 8 patients. In addition, an association with adenocarcinoma was identified in 7 of the 13 cases. All 7 carcinomas accompanied by inverted HGPIN were conventional acinar adenocarcinoma cases; of note, for these 7 cases, the Gleason score was 7 for each. One acinar adenocarcinoma case accompanying inverted HGPIN demonstrated hobnail characteristics in large areas of the invasive component. It was observed that nuclei were proliferated in the invasive cribriform glands, which was comparable to that of inverted HGPIN, and were located on the cytoplasmic luminal surface; a similar morphology was also observed in individual glands. In conclusion, the results of the present study suggested that the hobnail HGPIN pattern may be of diagnostic importance due to its high association with adenocarcinoma and the high Gleason scores in the accompanying carcinomas.
dc.identifier.doi10.3892/ol.2015.3584
dc.identifier.endpage2399
dc.identifier.issn1792-1074
dc.identifier.issn1792-1082
dc.identifier.issue4en_US
dc.identifier.pmid26622858
dc.identifier.scopus2-s2.0-84940061812
dc.identifier.scopusqualityQ3
dc.identifier.startpage2395
dc.identifier.urihttps://doi.org/10.3892/ol.2015.3584
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8478
dc.identifier.volume10
dc.identifier.wosWOS:000362999500080
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖznur, Meltem
dc.language.isoen
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofOncology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectinverted
dc.subjecthobnail
dc.subjectprostatic intraepithelial neoplasia
dc.subjectprostate
dc.subjectadenocarcinoma
dc.subjectNeedle-Biopsy
dc.subjectFollow-Up
dc.subjectCarcinoma
dc.subjectClassification
dc.subjectPathology
dc.subjectLesions
dc.subjectCancer
dc.titleInverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
8478.pdf
Boyut:
885.4 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu