Bias in the prenatal lung measurements in fetal congenital diaphragmatic hernia with intrauterine growth restriction

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dc.contributor.authorAydin, Emrah
dc.contributor.authorKhanmammadova, Narmina
dc.contributor.authorBurns, Patricia
dc.contributor.authorLim, Foong-Yen
dc.contributor.authorHabli, Mounira A.
dc.contributor.authorPeiro, Jose Luis
dc.date.accessioned2024-10-29T17:58:53Z
dc.date.available2024-10-29T17:58:53Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjectives: The failure of a fetus to develop to its full potential due to maternal or placental factors is known as intrauterine growth restriction (IUGR). Fetal head growth is usually preserved in that situation producing a potential discordance between head and body size. Our goal is to discover if IUGR has an impact on the prenatal ultrasound measurements taken to assess pulmonary development in congenital diaphragmatic hernia (CDH). Methods: A retrospective chart review (IRB#2017-6361) was performed on all prenatally diagnosed CDH patients from 2007 to 2016. Patient demographics, fetal and neonatal anthropometric measurements, and fetal lung parameters were the main subjects of the data that were gathered. Fetal growth was assessed by the curves based on US data by Olsen et al. and by Peleg et al. Of 147 CDH patients, 19 (12.9 %) patients were diagnosed with IUGR before the 30th gestational week while there were 20 (13.6 %) patients after the 30th gestational week. Results: Patients with IUGR and the observed-to-expected lung-to-head ratio (O/E LHR) less than 25 % had better survival rates both to discharge and date compared to non IUGR group (p=0.226, OR 2.25 95 % CI 0.60-1.08 and p=0.175, OR 2.40 95 % CI 0.66-1.17, respectively). Moreover, the ECMO need of the patients who had IUGR and O/E LHR less than 25 % was significantly less than the patients without IUGR (38.5 vs. 80.0 %, p=0.005). Conclusions: This study confirms that the intrauterine measurements to predict pulmonary hypoplasia in CDH patients are misleading in the presence of IUGR and cause an overestimation.
dc.identifier.doi10.1515/jpm-2023-0425
dc.identifier.endpage551
dc.identifier.issn0300-5577
dc.identifier.issn1619-3997
dc.identifier.issue5en_US
dc.identifier.pmid38634775
dc.identifier.scopus2-s2.0-85195228580
dc.identifier.scopusqualityQ2
dc.identifier.startpage546
dc.identifier.urihttps://doi.org/10.1515/jpm-2023-0425
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14546
dc.identifier.volume52
dc.identifier.wosWOS:001205274600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofJournal of Perinatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcongenital diaphragmatic hernia
dc.subjectintrauterine growth restriction
dc.subjectlung-to-head ratio (LHR)
dc.subjectobserved-to-expected LHR (O/E LHR)
dc.subjectfetal growth restriction
dc.titleBias in the prenatal lung measurements in fetal congenital diaphragmatic hernia with intrauterine growth restriction
dc.typeArticle

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