The effect of distension pressure on endothelial injury and vasodilatation response in saphenous vein grafts: conversion of a bypass graft to a dead pipe

Basit Öğe Kaydı
dc.authorid0000-0003-4118-040X
dc.authorscopusid14008084500
dc.authorscopusid10139012600
dc.authorscopusid6506413443
dc.authorscopusid12786699400
dc.authorscopusid25622097700
dc.authorscopusid55317577700
dc.authorscopusid7003875728
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.contributor.authorGürkan, Selami
dc.contributor.authorGür, Özcan
dc.contributor.authorYüksel, Volkan
dc.contributor.authorTastekin, Ebru
dc.contributor.authorHüseyin, Serhat
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorCanbaz, Suat
dc.date.accessioned2022-05-11T14:35:58Z
dc.date.available2022-05-11T14:35:58Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractIntroduction: Endothelial damage caused by high pressure applied for spasm relaxation during graft preparation is one of the most plausible theories explaining early graft failure. Aim of the study: We aimed to demonstrate the extent of endothelial damage in saphenous vein grafts distended to different pressure levels by using immunohistochemical methods and in vitro tissue baths. Material and methods: Saphenous vein grafts (SVGs) of 25 patients who underwent isolated elective CABG surgery were used in this study. By using a specific mechanism, SVGs were distended to five different pressure levels for two minutes: 0 mmHg, 50 mmHg, 100 mmHg, 200 mmHg, 300 mmHg. In vitro tissue baths and immunohistochemical examinations were performed. Results: None of the grafts distended to 300 mmHg pressure were functional in the tissue bath system. The relaxation response to carbachol of SVGs distended to 0, 50, 100 and 200 mmHg was 97.87 +/- 4.47%, 98.52 +/- 3.95%, 93.78 +/- 3.64%, and 30.87 +/- 4.11%, respectively. There were no statistically significant differences in terms of relaxation responses between samples distended to 0, 50, and 100 mmHg (p = 0.490). The relaxation response of samples distended to 200 mmHg was significantly decreased (p = 0.021). The endothelia of samples distended to 0 mmHg were almost intact in CD31 staining. Endothelial cell loss occurred at all tested distension pressures at different degrees. Conclusion: In vitro and immunohistochemical studies revealed that distending an SVG used for coronary artery bypass grafting with pressures of 100 mmHg or less results in less endothelial damage and increases graft patency.
dc.identifier.doi10.5114/kitp.2014.43836
dc.identifier.endpage125
dc.identifier.issn1731-5530
dc.identifier.issn1897-4252
dc.identifier.issue2en_US
dc.identifier.pmid26336407
dc.identifier.scopus2-s2.0-84904124289
dc.identifier.scopusqualityQ3
dc.identifier.startpage119
dc.identifier.urihttps://doi.org/10.5114/kitp.2014.43836
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8319
dc.identifier.volume11
dc.identifier.wosWOS:000216690800002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGürkan, Selami
dc.institutionauthorGür, Özcan
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofKardiochirurgia I Torakochirurgia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsaphenous vein
dc.subjectbypass
dc.subjectendothelial injury
dc.subjectvasodilatation
dc.titleThe effect of distension pressure on endothelial injury and vasodilatation response in saphenous vein grafts: conversion of a bypass graft to a dead pipe
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
8319.pdf
Boyut:
498.7 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu