Familial Mediterranean Fever Patients may have Unmet Needs for the Treatments of Exertional Leg Pain and Enthesitis

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dc.authorscopusid15053582500
dc.authorscopusid55892516600
dc.authorscopusid56086888000
dc.authorscopusid15127959300
dc.authorscopusid55989468100
dc.contributor.authorTezcan, Mehmet Engin
dc.contributor.authorVolkan, Ömür
dc.contributor.authorMercan, Rıdvan
dc.contributor.authorŞen, Nesrin
dc.contributor.authorYılmaz Öner, Sibel
dc.date.accessioned2022-05-11T14:40:01Z
dc.date.available2022-05-11T14:40:01Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: Exertional leg pain (ELP) and enthesitis are musculoskeletal findings in familial Mediterranean fever (FMF). They are not accepted as principal treatment targets. In this study, we assessed the effectiveness of treatments on ELP and enthesitis. Material and methods: We have included 218 FMF patients to the study. We retrospectively compared the FMF attacks’ frequency, duration and intensity (FMF attack VAS score) and levels of ELP VAS and enthesitis VAS scores between pre-treatment stage and while patients were on treatment at the last visit. Results: Forty-nine (22.5%) and 52 (23.9%) of the patients had enthesitis and ELP respectively. All patients were on colchicine treatment. Serositis attacks respond the treatments significantly. Moreover, both ELP VAS scores (p = 0.002) and enthesis VAS scores (p = 0.17) were improved with treatment. But only improvement in ELP VAS scores was significant. Conclusion: FMF treatments had favourable effect on ELP and enthesitis in FMF patients. However, the response rates would be inadequate. Therefore, there would be unmet need for treatment of both conditions. © 2021 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
dc.identifier.doi10.1016/j.reuma.2021.02.008
dc.identifier.issn1699-258X
dc.identifier.pmid33846104
dc.identifier.scopus2-s2.0-85104467932
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.reuma.2021.02.008
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8834
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMercan, Rıdvan
dc.language.isoen
dc.publisherEdiciones Doyma, S.L.
dc.relation.ispartofReumatologia Clinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEnthesitis
dc.subjectExertional leg pain
dc.subjectFamilial Mediterranean fever
dc.subjectVisual analog score
dc.titleFamilial Mediterranean Fever Patients may have Unmet Needs for the Treatments of Exertional Leg Pain and Enthesitis
dc.title.alternativeLos pacientes con fiebre mediterránea familiar podrían tener necesidades no satisfechas de tratamiento del dolor en piernas con el esfuerzo y entesitis]
dc.typeArticle

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