Predictive Importance of Ultrasonography and Anti-Thyroid Antibodies in the Management of Thyroid Nodules in Indeterminate Cytology

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dc.contributor.authorPeduk, Şevki
dc.contributor.authorBenek, Suat
dc.date.accessioned2023-05-06T17:22:10Z
dc.date.available2023-05-06T17:22:10Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractObjectives: The aim of this study is to examine the effects of ultrasonography and serum anti-thyroid antibody (ATAb)levels in predicting malignancy in cases where molecular tests cannot be performed in indeterminate thyroid nodules. Methods: Ultrasonographic features of the dominant thyroid nodule of a total of 228 patients who were operated for nodular goiter were analyzed and preoperative serum ATAb levels were examined. Especially in Bethesda category 3 nodules correlation of these parameters with malignancy rates and Hashimoto’s thyroiditis (HT) was investigated. Results: Malignancy was detected in 24.5% (12/49) Bethesda Category 3 nodules. Anti-thyroglobulin (Anti-TG) and-or anti-thyroid peroxidase (anti-TPO) positivity in serum 36.5% (72/197) was correlated with histopathologically proven HT (p=0.001). Poor prognostic factors were found to be less common in HT-associated papillary thyroid cancer (PTC). Ultrasonographic characteristics such as hypoechogenicity, microcalcification, and border irregularity were significant in predicting malignancy in indeterminate nodules (p=0.038- 0.003- 0.004, respectively). The central vascularization pattern remained in the background compared to other parameters (p=0.059). In the presence of ultrasonographic halo, 92.7% (51/55) of the nodules were benign (p=0.001). Conclusion: In the management of thyroid nodules in indeterminate cytology, suspicious ultrasonographic features and Hashimoto's thyroiditis should be encouraging in making the surgical decision.
dc.identifier.doi10.14744/ejmi.2021.74599
dc.identifier.endpage127
dc.identifier.issn2602-3164
dc.identifier.issue1en_US
dc.identifier.startpage122
dc.identifier.trdizinid533665
dc.identifier.urihttps://doi.org/10.14744/ejmi.2021.74599
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/533665
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12093
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBenek, Suat
dc.language.isoen
dc.relation.ispartofEurasian Journal of Medical Investigation
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePredictive Importance of Ultrasonography and Anti-Thyroid Antibodies in the Management of Thyroid Nodules in Indeterminate Cytology
dc.typeArticle

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