Evaluation of silent cerebral lesions in patients with first ischemic stroke attack

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dc.authorscopusid56148812400
dc.authorscopusid6603214291
dc.authorscopusid16069377400
dc.authorscopusid55768701700
dc.authorscopusid56148027400
dc.authorscopusid55185169500
dc.contributor.authorDemirel, E.A.
dc.contributor.authorEmre, Ufuk
dc.contributor.authorÜnal, A.
dc.contributor.authorÖzen, B.
dc.contributor.authorTu?rul Atasoy, H.
dc.contributor.authorÖztürk, F.
dc.date.accessioned2022-05-11T14:40:13Z
dc.date.available2022-05-11T14:40:13Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractBackground: We aimed to evaluate the frequency of silent cerebral lesions (silent cerebral infarction (SCI) and leukoaraiosis (LA)) in first-ever ischemic stroke patients. We wanted to identify the risk factors related with silent cerebral lesions, and the impact of these lesions on the prognosis of patients. Materials and methods: A total of 114 (58 male/56 female) patients with first-ever ischemic stroke that underwent brain MRI were enrolled in this study. Clinical features, and laboratory results were compared in the patients with and without SCI. They were also compared with LA severity, and the risk factors were evaluated. Results: SCI was detected in 90 patients and the most common location was periventricular white matter (PWM) (33%). High body mass index (BMI), hypertension (HT), and hyperlipidemia (HL) were associated with SCI (p = 0.023, 0.012, and 0.019). No associations were detected with LA (p > 0.05). The cholesterol (p = 0.011) and LDL (p = 0.009) levels of the multiple-SCI group were higher than those of the single-SCI group. Lower ejection fraction (EF) was associated with SCI and the severity of LA (p = 0.029 and 0.036). Hemoglobin and hematocrit values were low in advanced-periventricular white matter hyperintensity (adv-PWMH).The presence of SCI had no effects, on stroke recurrence, mortality, or prognosis. Multiple logistic regression analysis showed that HL and the presence of adv-PWMH were independent risk factors for SCI. Conclusion: While some parameters are associated with presence of SCI and LA, other parameters are related only with presence of LA. Different factors may play a role in development of SCI and LA. Studies on larger populations are needed for further evaluation of this issue. © 2011 Elsevier GmbH. All rights reserved.
dc.identifier.doi10.1016/j.npbr.2011.12.001
dc.identifier.endpage26
dc.identifier.issn0941-9500
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84855852587
dc.identifier.scopusqualityQ3
dc.identifier.startpage22
dc.identifier.urihttps://doi.org/10.1016/j.npbr.2011.12.001
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8907
dc.identifier.volume18
dc.indekslendigikaynakScopus
dc.institutionauthorÜnal, A.
dc.language.isoen
dc.relation.ispartofNeurology Psychiatry and Brain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFirst ischemic stroke
dc.subjectLeukoaraiosis
dc.subjectSilent cerebral infarction
dc.subjectSilent cerebral lesions
dc.subjectcholesterol
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbody mass
dc.subjectbrain damage
dc.subjectbrain infarction
dc.subjectbrain ischemia
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectdisease severity
dc.subjectfemale
dc.subjectheart ejection fraction
dc.subjecthematocrit
dc.subjecthuman
dc.subjecthyperlipidemia
dc.subjecthypertension
dc.subjectlaboratory test
dc.subjectleukoaraiosis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectnuclear magnetic resonance imaging
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectrecurrent disease
dc.subjectrisk factor
dc.subjectwhite matter
dc.titleEvaluation of silent cerebral lesions in patients with first ischemic stroke attack
dc.typeArticle

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