Association of Pb, Cd, and Se Concentrations and Oxidative Damage-Related Markers in Different Grades of Prostate Carcinoma

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dc.authorscopusid23968920100
dc.authorscopusid44661297900
dc.authorscopusid8713588200
dc.authorscopusid55979457200
dc.authorscopusid6602449225
dc.authorscopusid15051503900
dc.authorscopusid7006833103
dc.authorwosidAksu, Abdullah/AAB-8463-2020
dc.contributor.authorGüzel, Savaş
dc.contributor.authorKiziler, Lebriz
dc.contributor.authorAydemir, Birsen
dc.contributor.authorAlıcı, Bülent
dc.contributor.authorAtaus, Süleyman
dc.contributor.authorAksu, Abdullah
dc.contributor.authorDurak, Haydar
dc.date.accessioned2022-05-11T14:42:05Z
dc.date.available2022-05-11T14:42:05Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractProstate cancer is known to be affected by the heavy metal levels and oxidative damage of the body, yet there are very few studies which look into the way it occurs. The aim of this study was to determine whether blood and tissue lead (Pb), cadmium (Cd), and selenium (Se) levels are associated with oxidative damage in the context of prostate cancer progression and development. Seventy-nine patients comprising 25 patients with benign prostatic hypertrophy (BPH), 23 patients with malignant prostatic carcinoma (malign Ca), 16 patients with low-grade prostatic intraepithelial neoplasia (LGPIN), and 15 patients with high-grade prostatic intraepithelial neoplasia (HGPIN) diagnosed on the basis of their clinical profile, transrectal ultrasonography, and histopathology were included in this study. Cd and Pb levels in whole blood were found to be increased in patients with HGPIN compared with the BPH group; also, the levels of Cd in whole blood and tissue were found to be increasing in patients with malign Ca, unlike BPH patients. Moreover, the levels of malondialdehyde (MDA) in plasma and tissue were significantly increased in malign Ca, LGPIN, and HGPIN than those in BPH. However, the levels of tissue Pb were found to be decreasing in BPH, unlike the malign Ca and HGPIN patients, and the levels of tissue protein carbonyls in malign Ca were significantly lower than those in HGPIN. The levels of tissue reduced glutathione (GSH) in malign Ca were significantly lower than those in BPH. Additionally, the levels of Se in serum and tissue in LGPIN were significantly lower than those in BPH. The serum Se levels in HGPIN were also significantly lower than those in BPH and malign Ca groups. Furthermore, the concentrations of serum Se in LGPIN were significantly lower than those in malign Ca. From the Pearson correlation analysis, there were significant positive correlations between tissue Cd and MDA levels in malign Ca, LGPIN, and HGPIN and between the tissue Pb and tissue MDA and protein carbonyl levels in malign Ca. Blood Pb and tissue Pb were also significantly positively correlated with plasma MDA and protein carbonyl levels in malign Ca. In addition, blood Pb was significantly positively correlated with tissue MDA and protein carbonyl levels in malign Ca, and a significant positive correlation was also found between blood Cd and plasma protein carbonyls and tissue MDA in LGPIN. We observed that altered prooxidant-antioxidant balance and heavy metal levels may lead to an increase in oxidative damage and may consequently play an important role in prostate carcinogenesis. These findings indicate that changes in the levels of Pb, Cd, Se, MDA, protein carbonyls, and GSH in the blood and/or tissue are related to the prostatic carcinoma development and progression, although triggering one of the mentioned changes is unknown; therefore, further study is required to determine the exact steps of the process and clarify the roles of different substances in order to obtain a more detailed explanation of the phenomenon.
dc.description.sponsorshipIstanbul UniversityIstanbul University [BYP-2621/30062008]
dc.description.sponsorshipThis work was supported by The Research Fund of Istanbul University (Project BYP-2621/30062008).
dc.identifier.doi10.1007/s12011-011-9162-2
dc.identifier.endpage32
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid21809052
dc.identifier.scopus2-s2.0-84857357326
dc.identifier.scopusqualityQ1
dc.identifier.startpage23
dc.identifier.urihttps://doi.org/10.1007/s12011-011-9162-2
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9206
dc.identifier.volume145
dc.identifier.wosWOS:000299090300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCadmium
dc.subjectLead
dc.subjectSelenium
dc.subjectMDA
dc.subjectProtein carbonyl
dc.subjectGSH
dc.subjectProstate cancer
dc.subjectHistology grade
dc.subjectAntioxidant Enzyme-Activities
dc.subjectLipid-Peroxidation
dc.subjectCancer Patients
dc.subjectTrace-Elements
dc.subjectDna-Repair
dc.subjectStress
dc.subjectCadmium
dc.subjectBenign
dc.subjectGlutathione
dc.subjectBreast
dc.titleAssociation of Pb, Cd, and Se Concentrations and Oxidative Damage-Related Markers in Different Grades of Prostate Carcinoma
dc.typeArticle

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