Effects of mitomycin C and cyclosporine A on experimentally induced glaucoma filtration surgery in rabbit model

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dc.authorscopusid7006243697
dc.authorscopusid55316940600
dc.authorscopusid57193455230
dc.authorscopusid54973672700
dc.contributor.authorKılıç, Servet
dc.contributor.authorKulualp, Kadri
dc.contributor.authorMuzoğlu, Orhan
dc.contributor.authorÖzkaraca, Mustafa
dc.date.accessioned2022-05-11T14:34:57Z
dc.date.available2022-05-11T14:34:57Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractThe present study aims at investigating the effect of topical administration of mitomycin C (MMC) used solely and combined with cyclosporine A (MMC+CsA) on inhibition of the granulation tissue proliferation in experimentally induced glaucoma filtration surgery (GFS) in rabbits. A total of 18 New Zealand breed rabbits, control, MMC, and MMC+CsA groups of 6 subjects in each were used in the study. Clinical signs and complications in GFS region were evaluated using ophthalmoscopy, Schirmer tear test and tonometry 7 times at predetermined intervals between days 0-35. The right eyes of all subjects euthanized at the end of the study were harvested and histopathologically evaluated. According to clinical findings, GFS remained patent in all group subjects during the study except two subjects in the control group. Histopathological examination revealed marked cellular activities around GFS of the control group subjects as compared to the MMC and MMC+CsA groups. In this respect, no difference exists between two experimental groups. It has been observed that the intraocular pressure (IOP) value significantly decreased (P<0.005) in all groups on the day 5, which continued until the day 25 in control and MMC groups, and until the day 20 in the MMC+CsA group. The change in tear production rate showed to be more stable in the MMC+CsA than in the control and MMC groups. MMC and MMC+CsA are determined to have inhibited successfully granulation tissue proliferation around GFS and no marked difference was found between them as compared to the control group. It is suggested that in order to observe difference between these two groups, a more prolonged study is required.
dc.identifier.endpage331
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue45637en_US
dc.identifier.scopus2-s2.0-85014083926
dc.identifier.scopusqualityQ3
dc.identifier.startpage323
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8154
dc.identifier.volume167
dc.identifier.wosWOS:000396187500005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKılıç, Servet
dc.language.isoen
dc.publisherEcole Nationale Veterinaire Toulouse
dc.relation.ispartofRevue De Medecine Veterinaire
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectrabbit
dc.subjectglaucoma filtration surgery
dc.subjectmitomycin C
dc.subjectcyclosporine A
dc.subjectFiltering Surgery
dc.subjectCombined Trabeculectomy
dc.subject5-Fluorouracil
dc.subjectImplantation
dc.subjectFibrosis
dc.titleEffects of mitomycin C and cyclosporine A on experimentally induced glaucoma filtration surgery in rabbit model
dc.typeArticle

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