Effects of calcineurin inhibitors, cyclosporine A and tacrolimus (FK506), on the activity of antifungal drugs against Candida spp

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dc.authoridDag, Ilknur/0000-0002-7352-8653
dc.authoridSen, Sumeyye/0000-0002-1237-0864
dc.authoridAygun, Gokhan/0000-0001-6915-9843
dc.contributor.authorKaya, Sümeyye Şen
dc.contributor.authorKiraz, Nuri
dc.contributor.authorBarış, Ayşe
dc.contributor.authorTuran, Deniz
dc.contributor.authorÖz, Yasemin
dc.contributor.authorDağ, İlknur
dc.contributor.authorAygün, Gökhan
dc.date.accessioned2023-04-20T08:01:19Z
dc.date.available2023-04-20T08:01:19Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractIntroduction. The simultaneous use of antifungals with immunosuppressive agents has become a necessity for patients taking immunosuppressive therapy. However, antifungal drugs are problematic because of their limited target. Hypothesis. Scientists have been searching for new antifungals and some compounds with at least additive effects on antifungals. Calcineurin inhibitors used as immunosuppressive agents also attract attention due to their antifungal property. Aim. To evaluate the activity of two calcineurin inhibitors alone and in combination with amphotericin B (AMB), caspofungin (CAS), itraconazole (ITR), voriconazole (VOR) and fluconazole (FLU). Methodology. MICs of AMB, CAS, ITR, VOR, FLU and cyclosporine A (CsA) and tacrolimus (TAC) as calcineurin inhibitors were evaluated by the broth microdilution method against Candida albicans (n=13), C. krusei (n=7) and C. glabrata (n=10). Checkerboard and time-kill methods were performed to investigate the activity of combining calcineurin inhibitors with antifungal drugs. Results. The lowest MIC values were detected with VOR for all Candida isolates tested. Although we did not detect any inhibition for CsA or TAC alone at concentrations tested in this study, the combinations of CAS with CsA showed the highest synergistic activity (36.7%) by the checkerboard method, and CAS with CsA and ITR with TAC combinations exhibited apparent synergistic interaction by the time-kill method. However, the combinations of both CsA and TAC with AMB resulted in antagonistic interactions, especially against C. krusei isolate in time-kill testing. Conclusion. Synergistic interactions in the combinations of TAC or CsA with antifungal drugs, except for AMB. in many concentrations was found to be promising in terms of the treatment of patients with fungal infections.
dc.description.sponsorshipResearch Fund of Istanbul University [23844]; Scientific and Technological Research Council of Turkey (TUBITAK) [112S503]
dc.description.sponsorshipThe present work was supported by the Research Fund of Istanbul University (Project No. 23844), and Scientific and Technological Research Council of Turkey (TUBITAK) (Project No.112S503).
dc.identifier.doi10.1099/jmm.0.001354
dc.identifier.issn0022-2615
dc.identifier.issn1473-5644
dc.identifier.issue4en_US
dc.identifier.pmid33915075
dc.identifier.scopus2-s2.0-85105236589
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1099/jmm.0.001354
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10872
dc.identifier.volume70
dc.identifier.wosWOS:000787818300012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKiraz, Nuri
dc.language.isoen
dc.publisherMicrobiology Soc
dc.relation.ispartofJournal of Medical Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntifungal
dc.subjectCalcineurin Inhibitors
dc.subjectCombination
dc.subjectSynergistic Interaction
dc.subjectIn-Vitro Interactions
dc.subjectTime-Kill
dc.subjectCryptococcus-Neoformans
dc.subjectFluconazole
dc.subjectCombination
dc.subjectAlbicans
dc.subjectAgents
dc.subjectGlabrata
dc.subjectCaspofungin
dc.subjectAntagonism
dc.titleEffects of calcineurin inhibitors, cyclosporine A and tacrolimus (FK506), on the activity of antifungal drugs against Candida spp
dc.typeArticle

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