Cross-regulation of non-coding RNAs and their correlations with target protein-coding genes in CRC pathobiology

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dc.authorscopusid56497061100
dc.authorscopusid36772919600
dc.contributor.authorBozgeyik, Esra
dc.contributor.authorBozgeyik, İbrahim
dc.date.accessioned2022-05-11T14:05:11Z
dc.date.available2022-05-11T14:05:11Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractIlluminating the correlations between non-coding RNAs and protein-coding genes are of great interest to understand more about the molecular mechanisms that drive malignant transformation and understanding such correlations will enable development of more specific and efficient targeted therapeutics. Accordingly, in this comprehensive meta-analysis study, we tried to determine correlations between long non-coding RNA (lncRNA), microRNA (miRNA) and messenger RNA (mRNA) molecules that are involved in the pathogenesis of colorectal cancer (CRC). For the present study, current colorectal cancer studies published until 20 August 2017 and associated with the lncRNA-miRNA-mRNA interactions was included. The current literature search was done online in Pubmed, Embase and Web of Science databases. These databases have been screened with three keywords; “lncRNA” “miRNA” and “colorectal cancer”. As a result, colorectal neoplasia differentially expressed (CRNDE) was determined to be consistently up-regulated in CRC tissues and inversely associated with miR-181a-5p. Also, CRNDE expression was significantly associated with lymph node metastasis (p = 0.032). Additionally, a significant association was determined between CRC and survival time in the OS analysis of FER1L4, TUSC7, UCC and lincRNA-ROR. More importantly, there was a negative correlation between lncRNA-miRNA expressions (p = 0.001). Particularly, CRNDE/miR-181a-5p, FER1L4/miR-106a-5p, TUSC7/miR-211, UCC/miR-143 and lincRNA-ROR/miR-145 was negatively correlated. In addition, there was a significant positive correlation between GAPLINC/CD44 and TUSC7/CDK6 in CRC tissues (p = 0.000). Overall analysis showed that lncRNAs and mRNAs, which are targets of the same miRNA, have positive interactions. In addition, miRNAs were shown to have negative correlations with target lncRNA/mRNA. © 2018 Elsevier B.V.
dc.identifier.doi10.1016/j.mgene.2018.12.001
dc.identifier.endpage184
dc.identifier.issn2214-5400
dc.identifier.scopus2-s2.0-85057763389
dc.identifier.scopusqualityQ4
dc.identifier.startpage174
dc.identifier.urihttps://doi.org/10.1016/j.mgene.2018.12.001
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4915
dc.identifier.volume19
dc.identifier.wosWOS:000455678900028
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBozgeyik, Esra
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofMeta Gene
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectColorectal cancer
dc.subjectCRC
dc.subjectCRNDE
dc.subjectlncRNA
dc.subjectMeta-analysis
dc.subjectmiRNA
dc.subjectmessenger RNA
dc.subjectmicroRNA
dc.subjectmicroRNA 181a 5p
dc.subjectunclassified drug
dc.subjectuntranslated RNA
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcancer prognosis
dc.subjectcell cycle
dc.subjectcell invasion
dc.subjectcell migration
dc.subjectcell proliferation
dc.subjectcolony formation
dc.subjectcolorectal cancer
dc.subjectcontrolled study
dc.subjectdisease free survival
dc.subjectdown regulation
dc.subjectgene control
dc.subjecthuman
dc.subjectlymph node metastasis
dc.subjectmeta analysis
dc.subjectmRNA expression level
dc.subjectoverall survival
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectupregulation
dc.titleCross-regulation of non-coding RNAs and their correlations with target protein-coding genes in CRC pathobiology
dc.typeArticle

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