Endothelial Nitric Oxide Synthase and Angiotensin Converting Enzyme Gene Polymorphisms in Migraine Patients

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dc.authorid0000-0002-3488-3740
dc.authorid0000-0002-9006-1880
dc.authorscopusid24767004000
dc.authorscopusid24068634800
dc.authorscopusid12752983500
dc.authorscopusid35186504000
dc.authorscopusid24767236400
dc.authorscopusid6506764463
dc.authorscopusid6603267445
dc.authorwosidPalabıyık, Orkide/Q-2792-2019
dc.contributor.authorSipahi, Tammam
dc.contributor.authorGüldiken, Babürhan Feyzullah
dc.contributor.authorKabayel, Levent
dc.contributor.authorPalabıyık, Orkide
dc.contributor.authorÖzkan, Hülya
dc.contributor.authorOkman Kılıç, Tülay
dc.contributor.authorTurgut, Nilda
dc.date.accessioned2022-05-11T14:12:40Z
dc.date.available2022-05-11T14:12:40Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Ana Bilim Dalı
dc.description.abstractIntroduction: In this study, we investigated the association of migraine with the Variable Number of Tandem Repeats (VNTR), repeated as 27 base pair, gene polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) and the insertion/deletion of angiotensin converting enzyme (ACE) gene polymorphisms. Methods: One hundred and five migraine and ninety seven healthy female control subjects were enrolled in the study. The patients were subdivided as migraine with aura and without aura, and the frequency and severity of migraine headaches were recorded. The eNOS VNTR (eNOS 4 a/b) and ACE insertion/deletion gene polymorphisms (ACE I/D) were assessed by polymerase chain reactions. Results: The allele and genotype frequencies of eNOS 4 a/b gene polymorphism showed no difference between the migraine and control groups. The genotypic distribution of the ACE I/D gene polymorphism in the migraine group significantly differed from that in the control group. The DD and ID genotype increased the risk of migraine as much as 2.571 (95% CI-1.138-5.811) and 4.453 (95% CI-2.006-9.883) compared to the II genotype. The same increased risk sustained for both genotypes in the migraine with aura subgroup, but only the ID genotype remained as the risk factor in the migraine without aura subgroup (OR-3.750, 95% CI-1.493-9.420). No association of gene polymorphisms with migraine frequency and severity was observed. Conclusion: Our findings support the relationship between migraine and the ACE I/D gene polymorphism. However, no association was found between migraine and the eNOS 4 a/b gene polymorphism.
dc.identifier.doi10.4274/npa.y6665
dc.identifier.endpage278
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue3en_US
dc.identifier.pmid28360555
dc.identifier.scopus2-s2.0-84884575353
dc.identifier.scopusqualityQ3
dc.identifier.startpage274
dc.identifier.urihttps://doi.org/10.4274/npa.y6665
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5633
dc.identifier.volume50
dc.identifier.wosWOS:000325969200014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTurgut, Nilda
dc.language.isotr
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMigraine
dc.subjectgenetic polymorphism
dc.subjectnitric oxide synthase
dc.subjectangiotensin converting enzyme
dc.subjectInsertion Deletion Polymorphism
dc.subjectRisk-Factor
dc.subjectGlu298asp Polymorphism
dc.subjectAce
dc.subjectAssociation
dc.subjectDisease
dc.titleEndothelial Nitric Oxide Synthase and Angiotensin Converting Enzyme Gene Polymorphisms in Migraine Patients
dc.title.alternativeMigren hastalari{dotless}nda endotelyal nitrik oksit sentaz ve anjiyotensin dönüştürücü enzim gen polimorfizmleri]
dc.typeArticle

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