Intravitreal bevacizumab versus bevacizumab and 1 mg triamcinolone acetonide in eyes with bilateral diabetic macular edema

Küçük Resim Yok

Tarih

2019

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

International Journal of Ophthalmology (c/o Editorial Office)

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

AIM: To compare of intravitreal bevacizumab and intravitreal bevacizumab and triamcinolone acetonide in eyes with bilateral diabetic macular edema. METHODS: In this retrospective comparative-randomized study, 42 eyes of 21 diabetic patients with bilateral macular edema were evaluated. In one eye intravitreal injection of 1.25 mg bevacizumab (IVB group) was performed and in the fellow eye intravitreal injection of combined 1.25 mg bevacizumab and 1 mg triamcinolone acetonide (IVTA-IVB group) was performed. Main outcomes were the central macular thickness (CMT) measured with optical coherence tomography (OCT), ETDRS visual acuity (VA) and intraocular pressure (IOP). RESULTS: Mean follow-up time was 4.7±1.5mo. In the IVB and IVTA-IVB groups, mean CMT was 494.7±114.4 ?m and 546.8±165.6 ?m before injections; 430.4±133.2 ?m and 363.7±105.3 ?m in first month; 484.8±167.4 ?m and 407.3±108.7 ?m in 3rd month; 550.4±191.5 ?m and 516.8±158 ?m after 6mo respectively. Differences were significant in first and 3rd months (P<0.05). In the IVB and IVTA-IVB groups, mean ETDRS VA score was 57.1±13.5 and 48.9±13.9 before injections; 62.2±14 and 58.8±12.1 in first month; 59±13.7 and 59.3±13.6 in 3rd month; 55.6±14.9 and 55.5±8.7 after 6mo respectively. Differences were significant in first and 3rd and 6mo (P<0.05). There was no IOP difference. IVTA-IVB group gains best VA in 3rd month after the first injection and maintains it for 6mo whereas IVB group gains best VA at first month and can be able to maintain for 3mo. CONCLUSION: Injection of 1 mg IVTA-IVB seems to be better than IVB alone in improving VA for 6mo without any steroid dependent complications. Copyright 2019 by the IJO Press.

Açıklama

Anahtar Kelimeler

Bevacizumab, KEYWORDS:diabetic retinopathy, Triamcinolone acetonide, bevacizumab, hemoglobin A1c, triamcinolone, triamcinolone acetonide, adult, aged, artery perfusion, Article, bilateral diabetic macular edema, central macular thickness, clinical article, clinical outcome, combination drug therapy, comparative study, controlled study, cornea limbus, diabetes mellitus, diabetic macular edema, diabetic patient, disease duration, female, follow up, hemoglobin blood level, human, hypertension, intraocular pressure, laser coagulation, male, monotherapy, oculoplethysmography, ophthalmoscopy, panretinal photocoagulation, proliferative diabetic retinopathy, retina artery, retrospective study, visual acuity

Kaynak

International Eye Science

WoS Q Değeri

Scopus Q Değeri

Q4

Cilt

19

Sayı

1

Künye