The influence of vitamin D deficiency on eradication rates of Helicobacter pylori

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dc.authorid0000-0002-2169-5548
dc.authorscopusid55445082300
dc.authorscopusid57004462100
dc.authorscopusid6506721526
dc.authorscopusid57200161113
dc.authorscopusid23979648200
dc.authorscopusid36608599700
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.authorwosidbilgic, yılmaz/ABI-6432-2020
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidYildirim, Tulay/AAB-5030-2021
dc.contributor.authorYıldırım, Oğuzhan
dc.contributor.authorYıldırım, Tülay
dc.contributor.authorSeçkin, Yüksel
dc.contributor.authorOsanmaz, Pelin
dc.contributor.authorBilgiç, Yılmaz
dc.contributor.authorMete, Rafet
dc.date.accessioned2022-05-11T14:39:55Z
dc.date.available2022-05-11T14:39:55Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground. Helicobacter pylori eradication therapy improves the healing of various gastro-duodenal diseases such as chronic gastritis and peptic ulcer, and also reduces gastric cancer incidence. Several studies have reported on risk factors other than antibiotic resistance related to Helicobacter pylori eradication failure. Objectives. In this study, we aimed to investigate whether or not the serum levels of 25-hydroxy-vitamin D (25(OH)D) influence eradication rates of H. pylori. Material and methods. 220 patients diagnosed with H. pylori gastritis using endoscopic biopsy had their 25-OH vitamin D levels measured via the electrochemiluminescence method before beginning eradication therapy of H. pylori. Gastric biopsies obtained at endoscopy were examined for H. pylori strains and histopathologic findings. All patients were treated with bismuth-containing quadruple therapy for 14 days. H. pylori eradication was determined via the 14C-urea breath test performed 4 weeks after the end of therapy. Based on the 25-OH vitamin D levels, the patients were divided into 2 groups: group 1 (deficient) had a vitamin D level of < 10 ng/mL, while group 2 (sufficient) had a vitamin D level of >= 10 ng/mL. Results. Eradication was successful in 170 (77.2%) patients and failed in 50 (22.7%) patients. The prevalence of 25(OH)D deficiency was 30.5%. Mean 25(OH)D levels were significantly lower in the eradication failure group compared to the successful treatment group (9.13 +/- 4.7 vs 19.03 +/- 8.13; p = 0.001). There were significantly more patients with deficient 25(OH)D levels in the failed treatment group compared to the successful treatment group (p = 0.001). Conclusions. Our findings suggest that 25-OH vitamin D deficiency may be considered a risk factor related to eradication failure of H. pylori, which may lead to a need for supplementation of vitamin D before eradication of H. pylori.
dc.identifier.doi10.17219/acem/65430
dc.identifier.endpage1381
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue9en_US
dc.identifier.pmid29442458
dc.identifier.scopus2-s2.0-85040018540
dc.identifier.scopusqualityQ1
dc.identifier.startpage1377
dc.identifier.urihttps://doi.org/10.17219/acem/65430
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8798
dc.identifier.volume26
dc.identifier.wosWOS:000426592000008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOsanmaz, Pelin
dc.institutionauthorMete, Rafet
dc.language.isoen
dc.publisherWroclaw Medical Univ
dc.relation.ispartofAdvances in Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectvitamin D
dc.subjectHelicobacter pylori
dc.subjectHelicobacter pylori eradication
dc.subject1,25-Dihydroxyvitamin D-3
dc.subjectTherapy
dc.subjectClarithromycin
dc.subjectCathelicidins
dc.subjectTuberculosis
dc.subjectPopulation
dc.subjectInfections
dc.subjectExpression
dc.subjectGastritis
dc.subjectImmunity
dc.titleThe influence of vitamin D deficiency on eradication rates of Helicobacter pylori
dc.typeArticle

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