Vitamin D deficiency as a risk factor for PFAPA syndrome

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dc.authorscopusid54791156900
dc.authorscopusid36165893600
dc.contributor.authorNalbantoğlu, Ayşin
dc.contributor.authorNalbantoğlu, Burçin
dc.date.accessioned2022-05-11T14:37:15Z
dc.date.available2022-05-11T14:37:15Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: The periodic fever, aphthous stomatitis, pharangytis and cervical adenitis (PFAPA) syndrome, is an idiopathic chronic disease of non-hereditary origin, primarily affecting pre-school children and is the most common periodic fever disorder in children. Rapid response to corticosteroid treatment suggest an immune dysregulation. Recently, emerging evidence suggest that vitamin D plays an important role in immunity regulation. The aim of our study was to assess the vitamin D levels in children with PFAPA syndrome. Methods: This study was conducted prospectively. We have consecutively evaluated 50 patients after having excluded other causes of recurrent fever between May 2017 and May 2018 in addition to age-matched 50 patients as control group. All patients has complete physical examination and laboratory tests. Laboratory tests included complete blood count, C-reactive protein (CRP), and vitamin D levels. Serum 25 (OH) vitamin D levels were measured in all patients twice yearly. Results: Vitamin D levels was 18 +/- 10 ng/ml in the patient group and 35 +/- 13 ng/ml in the control group. There was statistically significant difference between the groups (p < 0.001). 38 patients from the PFAPA group and 20 patients from the control group had low vitamin D levels. Multivariate logistic regression analysis showed that CRP (odd ratio (OR) = 2.7, 95% confidence interval (CI) = 2.4-4.1) and serum 25 (OH) vitamin D levels < 30 ng/ml OR = 2.1, 95% CI = 1.8-2.5) were associated with PFAPA occurrence. Conclusion: We found strong correlation between PFAPA and vitamin D insufficiency. Hypovitaminosis D can be a significant risk factor for PFAPA episode recurrence.
dc.identifier.doi10.1016/j.ijporl.2019.02.047
dc.identifier.endpage57
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.pmid30870794
dc.identifier.scopus2-s2.0-85062641993
dc.identifier.scopusqualityQ2
dc.identifier.startpage55
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2019.02.047
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8632
dc.identifier.volume121
dc.identifier.wosWOS:000469906400012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorNalbantoğlu, Ayşin
dc.institutionauthorNalbanto?lu, Burçin
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofInternational Journal of Pediatric Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVitamin D
dc.subjectPFAPA syndrome
dc.subjectChildren
dc.subjectPeriodic fever
dc.subjectPeriodic Fever
dc.subjectAphthous Stomatitis
dc.subjectAdenitis Pfapa
dc.subjectPharyngitis
dc.subjectAutoimmunity
dc.titleVitamin D deficiency as a risk factor for PFAPA syndrome
dc.typeArticle

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